摘要
目的:探讨纳洛酮治疗慢性阻塞性肺疾病呼吸衰竭的临床疗效。方法:选取2012年2月-2014年2月在笔者所在医院因慢性阻塞性肺疾病呼吸衰竭治疗的60例患者为研究对象,根据患者的病例资料将所有的患者进行分组,其中对照组28例予常规治疗,研究组32例予常规治疗+纳洛酮治疗。记录两组患者在治疗前后静脉血气分析中Pa O2、Pa CO2、FEV1/FVC的变化及患者的临床表现。结果:两组治疗后,对照组的总有效率为67.9%,研究组的总有效率为90.6%,两组总有效率比较差异有统计学意义(P<0.05);治疗后,两组Pa O2、Pa CO2、FEV1/FVC比较差异有统计学意义(P<0.05)。结论:纳洛酮在慢性阻塞性肺疾病呼吸衰竭治疗中疗效显著,能有效提高Pa O2的浓度、FEV1/FVC的比值,降低Pa CO2的浓度,从而提高临床疗效,值得临床参考。
Objective：To investigate the curative effects of Naloxone in the treatment of chronic obstructive pulmonary disease with respiratory failure in clinic.Method：60 cases of chronic obstructive pulmonary disease with respiratory failure therapy patients From February 2012 to February 2014 in our hospital were selected as the research object,according to the clinical data of patients they were divided into two groups,28 cases in the control group treated with conventional treatment,research group of 32 cases were treated with conventional therapy plus Naloxone treatment.The venous blood gas of Pa O2,Pa CO2,FEV1/FVC before and after treatment were recorded.Result：After treatment,the total efficiency of control group was 67.9%,the research group was 90.6%,the difference between the two groups was statistical significant（P〈0.05）;after treatment the Pa O,Pa C2O2 and FEV1/FVC in the two groups had statistical significant（P〈0.05）.Conclusion：The curative effect of Naloxone in the treatment of respiratory failure caused by chronic obstructive pulmonary disease is significant,it can effectively improve the FEV1/FVC and Pa O2,decrease the concentration of Pa CO2,so as to improve the clinical efficacy.It is worthy of clinical reference.
出处
《中外医学研究》
2014年第33期25-26,共2页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
纳洛酮
慢性阻塞性肺疾病
呼吸衰竭
Saloon
Chronic obstructive pulmonary disease
Respiratory failure
