摘要
目的探讨血清hs-CRP水平与脑出血患者出血量、病情、认知功能损害的关系。方法回顾性分析62例脑出血患者的临床资料,另选择健康体检者25例为对照组。检测患者及对照组血清hs-CRP水平;分析其与患者出血量、病情、认知功能的关系。结果脑出血患者第1天hs-CRP水平为(5.5±1.6)mg/L,第3天为(9.8±3.1)mg/L,第7天为(6.9±2.4)mg/L,不同时间点比较,差异有统计学意义(P<0.05)。第3天和第7天显著高于第1天,而第7天又显著低于第3天(P均<0.05)。对照组hs-CRP水平为(2.4±0.9)mg/L,显著低于脑出血患者(P<0.01)。患者血肿越大、NIHSS评分越高、存在认知功能障碍,则hs-CRP水平越高(P<0.01)。结论急性自发性脑出血患者在发病后CRP会发生动态变化,出血量越大、NIHSS评分越高,患者CRP水平也越高。
Objective To investigate the relationship between serum hs-CRP levels and bleeding volume,illness,cognitive impairment of patients with cerebral hemorrhage. Methods The clinical data of 62 patients with cerebral hemorrhage were retrospectively analyzed,and 25 healthy people were selected as control group. Serum hs-CRP levels were detected,and the relationship between serum hs-CRP levels and bleeding,illness,cognitive impairment was analyzed. Results The hs-CRP level on 1st day was（ 5. 5 ± 1. 6） mg / L in patients with cerebral hemorrhage,and that of on 3rd day was（ 9. 8 ± 3. 1） mg / L,and that of on7 th day was（ 6. 9 ± 2. 4） mg / L. Compare in different time points,the differences were significant（ P〈0. 05）. The hs-CRP level in the control group was（ 2. 4 ± 0. 9） mg / L,which was lower than that of the patients with cerebral hemorrhage（ P〈0. 01）.The hs-CRP levels were higher in patients with larger hematoma,higher NIHSS score and with cognitive dysfunction（ P〈0. 01）.Conclusion Patients with acute spontaneous intracerebral hemorrhage has dynamic changes of CRP,and larger amount of bleeding,higher NIHSS score,and the CRP levels are also high.
出处
《临床医学》
CAS
2014年第12期11-13,共3页
Clinical Medicine
关键词
脑出血
超敏C反应蛋白
认知功能
Cerebral hemorrhage bleeding
High-sensitivity C-reactive protein（hs-CRP）
Cognitive function
