摘要
目的了解山东省34所医院的重症监护病房(ICU)临床分离病原菌的耐药性,为临床抗菌药物合理使用提供参考依据。方法来自2012年1月1日-12月31日从山东省ICU细菌耐药监测协作网34所医院收集到的病原菌,采用纸片扩散法对分离的病原菌进行药敏试验,采用WHONET 5.6软件进行数据处理。结果共收集到病原菌8 208株,其中革兰阴性菌6 374株占77.65%,革兰阳性菌1 066株占12.99%,真菌768株占9.36%;铜绿假单胞菌对亚胺培南、美罗培南的耐药率分别为46.18%、45.97%,鲍氏不动杆菌对亚胺培南、美罗培南的耐药率分别为84.91%、83.42%;耐甲氧西林金黄色葡萄球菌、表皮葡萄球菌、溶血葡萄球菌的检出率为70.90%、81.74%、88.06%。结论 ICU临床分离病原菌以革兰阴性菌为主,病原菌的耐药性呈显著增长趋势,必须予以重视。
OBJECTIVE To investigate the drug resistance of clinical isolates of pathogens from intensive care units of 34 hospitals in Shandong province so as to provide guidance for reasonable clinical use of antibiotics. METHODS From Jan 1 ,2012 to Dec 31 ,2012 ,the pathogens were collected from 34 hospitals from the Collaboration network of ICU antimicrobial resistance monitoring of Shandong province ,then the drug susceptibility testing for the clini‐cal isolates of pathogens was performed by using disc diffusion method ,and the data were statistically analyzed with the use of WHONET 5. 6 software. RESULTS A total of 8 208 strains of pathogens have been isolated ,inclu‐ding 6 374 （77. 65% ） strains of gram‐negative bacteria ,1 066 （12. 99% ） strains of gram‐positive bacteria ,and 768 （9. 36% ） strains of fungi. The drug resistance rates of the P. aeruginosa to imipenem and meropenem were 46. 18% and 45. 97% ,respectively ;the drug resistance rates of the A. baumannii to imipenem and meropenem were 84. 91% and 83. 42% ,respectively. The detection rates of the methicillin‐resistant S. aureus ,Staphylococ‐cus epidermidis , and Staphylococcus haemolyticus were 70. 90% , 81. 74% , and 88. 06% , espectively. CONCLUSION The gram‐negative bacteria are dominant among the pathogens isolated from the ICUs ,the drug resistance of the pathogens show a remarkable increasing trend ,which should be paid great attention to.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2014年第24期6033-6035,共3页
Chinese Journal of Nosocomiology
基金
山东省自然科学基金资助项目(ZR2012HM005)
关键词
重症医学科
病原菌
分布
耐药性
Intensive care unit
Pathogen
Distribution
Drug resistance
