摘要
目的 通过检测良恶性梗阻性黄疸患者术前及术后血清B7-H3水平,了解其在梗阻性黄疸良恶性鉴别诊断方面的临床应用价值.方法 采集良性梗阻性黄疸32例及恶性梗阻性黄疸患者28例手术治疗前后的血清,通过酶联免疫吸附试验检测血清B7-H3浓度.结果 恶性梗阻性黄疸组血清B7-H3水平明显高于良性组（9334.57±1009.57） pg/mL vs（4450.81±406.92） pg/mL,差异具有显著的统计学意义（P＜0.01）;良恶性梗阻性黄疸组术后血清B7-H3水平较术前降低（2531.03 ±415.64） pg/mL vs（4450.81±406.92）pg/mL,（5833.00 ±2190.87） pg/mL vs（9334.57±1009.57） pg/mL,差异具有显著的统计学意义（P＜0.01）.结论 血清B7-H3参与机体炎症及肿瘤免疫应答,可用于梗阻性黄疸良恶性病因鉴别诊断.
Objective To investigated the significance of serum B7-H3 in differential diagnosis of patients with benign and malignant obstructive jaundice.Methods The B7-H3 levels in 60 patients with obstructive jaundice who were divided into benign （32 patients） and malignant （28 patients） obstructive jaundice group were tested by enzyme-linked immunosorbent assay before and after operation.Results The serum B7-H3 levels of malignant obstructive jaundice group were significantly higher than that of benign group （9334.57 ± 1009.57） pg/mL vs （4450.81 ± 406.92） pg/mL,（P 〈 0.01）.The B7-H3 levels of benign and malignant obstructive jaundice group after operation were significantly lower than those before operation （2531.03 ± 415.64） pg/mL vs （4450.81 ±406.92） pg/mL,（5833.00 ± 2190.87） pg/mL vs （9334.57±1009.57） pg/mL,（P〈0.01）.Conclusion B7-H3 participate in the inflammatory immune and tumor immune response,The serum B7-H3 can be used as differential diagnosis index of benign and malignant obstructive jaundice.
出处
《国际外科学杂志》
2014年第10期688-690,共3页
International Journal of Surgery
