摘要
泊沙康唑是口服的第2代三唑类广谱抗真菌药物,其抗真菌谱广,抗菌效力强,尤其对比较罕见而且威胁生命的侵袭性真菌感染有效,主要用于预防和治疗严重免疫功能缺陷患者的侵袭性真菌感染。泊沙康唑不仅在药效上强于第1代三唑类抗真菌药,如氟康唑和伊曲康唑,且根据临床经济学分析的结果,其具有更好的成本-效果。
Posaconazole is an oral second-generation triazole with extended-spectrum, and its approved indications include prophylaxis of invasive fungal diseases in immunocompromised patients, especially to treat the in- vasive infections by relatively rare but life-threatening fungus like Zygomycosis, Fusarium disease, coccidioidomycosis and so on. Posaconazole is not only more clinically effective than first-generation triazole antifungal drugs, for example, fluconazole and itraconazole, but also more cost-effective according to clinical economic analysis. In this paper, the strategy of treatment with posaconazole to invasive fungal infection was reviewed.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2014年第23期2739-2747,2757,共10页
Chinese Journal of New Drugs
关键词
泊沙康唑
深部真菌感染
临床疗效
临床经济学
成本-效果
成本-效用
posaconazole
invasive fungal infection
clinically effect
clinical economic analysis
cost-ef-fective
cost-utility
