摘要
目的了解泊沙康唑对侵袭性真菌感染治疗的研究进展,为临床用药指导提供依据。方法 2000年1月-2017年1月在Pubmed、SCI、CNKI和万方数据库检索关于泊沙康唑治疗侵袭性真菌感染研究的文献,用Endnote进行整理,按照发表年份、发文量、发文期刊、文献出版来源、被引频次等对最终纳入的文献进行分析,并排除无关文献。结果最终纳入文献481篇,其中中文4篇、英文477篇,其中病例分析321篇占66.7%,临床研究100篇占20.8%,回顾性分析60篇占12.5%,被引频次最高的是154次。结论泊沙康唑相对于传统抗真菌药物具有更高的安全性和有效性,可替代某些传统抗真菌药物用于恶性血液疾病或器官移植等免疫力低下患者预防或治疗真菌感染。
OBJECTIVE To investigate the development of posaconazole in the treatment of invasive fungal infection,so as to provide references for clinical medication guidance.METHODS All the publications about the research of posaconazole in the treatment of fungal infections from Pubmed,SCI,CNKI and Wanfang database from Jan.2000 to Jan.2017 were collected,statistical analysis by Endnote X7 was performed on the final involved articles according to the publication year,publication number,publication journals,published literatures sources and times cited,and irrelevant publications were excluded.RESULTS A total of 481 publications were included,including 4 Chinese articles and 477 English articles.Among which,321 were case study,accounting for 66.7%,100 were clinical research,accounting for 20.8%,and 60 were retrospective analysis,accounting for 12.5%.The highest cited frequency was 154 times.CONCLUSION Compared with the traditional antifungal agents,posaconazole has higher safety and effectiveness,and can replace some traditional antifungal agents for the prevention or treatment of fungal infections in patients with immune diseases,such as hematological malignancies or organ transplantation.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2017年第24期5537-5540,共4页
Chinese Journal of Nosocomiology
基金
"十二五"国家重大科技专项基金资助项目(2012ZX09303004-002)
关键词
泊沙康唑
侵袭性真菌感染
文献研究
计量分析
Posaconazole
Invasive fungal infection
Literature research
Quantitative analysis
