摘要
腺苷,作为机体内ATP代谢过程中的重要产物,通过激活腺苷受体(adenosine receptors,AR)(A1R、A2AR、A2BR、A3R)参与了机体的许多生理及病理过程的调节。腺苷受体在体内的各个组织器官具有广泛的分布,在免疫系统尤为丰富,如中性粒细胞、巨噬细胞、淋巴细胞、树突状细胞均有较高表达。炎症,是机体抵御外来刺激的一种防御性免疫机制,过度的炎症反应则会对机体造成损伤,中性粒细胞是其中重要的参与者之一,腺苷及其受体的调节密切参与了其黏附、迁移、细菌杀伤作用、炎症介质产生、凋亡等过程,从而对炎症起到调节作用。
Adenosine, an important metabolic product of ATP, regulates many physiological and pathological processes through activating different adenosine receptors （A1R, A2AR, A2BR, A3R）.There is a wide distribution of adenosine receptors in vari-ous tissues and organs particularly in immune system such as neutrophil, which is closely involved in the process of inflammation.In-flammation is defensive immune mechanism body resists external stimulus.The excessive inflammatory reaction will result in injury of the body in which neutrophils are one of the most important participants.The regulation of adenosine and its receptors on neutrophils plays an important role in adhesion, migration, bacterial killing effects, inflammatory mediators release, apoptosis and other processes.
出处
《医学研究生学报》
CAS
北大核心
2014年第11期1214-1218,共5页
Journal of Medical Postgraduates
基金
国家自然科学基金(31370913
81322044)
第三军医大学校级科研课题(2012XJQ01)
