摘要
目的 评价应用小儿肺热咳喘口服液联合阿奇霉素治疗肺炎支原体（MP）感染的临床价值，为中西医结合治疗儿童MP感染提供依据。方法 本研究为前瞻性、随机、开放、平行、阳性药物对照的多中心临床研究。2012年8月到2013年8月将符合入选标准及排除标准的疑似MP下呼吸道感染的发热伴咳嗽患儿作为研究对象，通过简单随机化分组方法分为治疗组和对照组，对照组应用阿奇霉素，治疗组除阿奇霉素外，联用小儿肺热咳喘口服液。收集所有患儿的临床病例资料、咽拭子标本和/或血清。应用巢式PCR 检测咽拭子标本中MP23SrRNA，ELISA法或乳胶凝集法检测血清中MP抗体。对PCR阳性和/或血清阳性的下呼吸道感染患儿的临床病例资料进行总结和统计分析。结果 对符合入选标准、同时咽拭子MP-DNA和/或血清MP抗体阳性的下呼吸道感染的79例患儿进行分析，对照组42例，治疗组37例，2组患儿在年龄、性别、治疗前病情方面差异无统计学意义（P 〈0.05）。治疗结束时，对2组患儿的临床疗效按病程进行分析，治疗组患儿的退热时间［（5.14±1.40）d比（6.12±2.45）d，P =0.014］、咳嗽减轻时间［（6.00 ±1.38）d比（6.92 ±1.63）d，P =0.026］及消失时间［（8.06±2.16）d比（9.83±2.60）d，P =0.036］均较对照组短，差异有统计学意义。结论 小儿肺热咳喘口服液联合阿奇霉素治疗儿童MP下呼吸道感染疗效优于单纯应用西药治疗，可作为临床辅助用药。
Objective To evaluate the effectiveness of traditional drug（ oral feirekechuan liquid for children） combined Azithromycin for children with Myeoplasma pneumoniae（MP） lower respiratory infection, and to provide optional method for the treatment of MP pneumonia with the combination approach. Methods This study was designed as prospective ,randomized ,open, paralleled, positive medicine controlled multi-center clinical trial. During Aug. 2012 to Aug. 2013, patients were included in the study who were suspected of MP infection in pediatric clinics and wards according to the inclusion criteria. All patients were randomly divided into two groups ： treatment group （ oral feirekechuan liquid for children plus Azithromyein ） and control group （Azithromycin）. Throat swab and serum specimens were ob- tained from patients, and also clinical data of all children were collected. MP DNA was detected by the nested PCR method with primers sets for amplification of the binding site of erythromycin at 23S rRNA. ELISA or particle agglutination method was applied to detect MP antibodies in serum. Clinical information of the patients was analyzed and their MP DNA was detected and/or MP-antibodies were positive. Results Seventy-nine patients with perfect clinical data and Nested PCR positive and/or MP-antibodies positive were analyzed. Thirty-seven patients received traditional chinese drug and Azithrolnycin（treatment group） and 42 patients received only Azithromycin（ control group）. There were no statistical significance in the sex, age, patients＇ fundamental conditions between the two groups. After treatment, in the treatment group the time of the fever was shorter than the control group [ （ 5.14 ± 1.40） d vs （ 6.12 ± 2.45 ） d, P = 0. 014]. Also, the treatment group took less time for coughing reduction [ （ 6.00 ± 1.38 ） d vs （6.92 ± 1.63 ） d, P = 0. 026] and disappearing[ （8.06 ±2.16） d vs （9.83 ±2.60） d,P =0.036]. Conclusions Oral feirekechuan liquid for children combined wi
出处
《中华实用儿科临床杂志》
CAS
CSCD
北大核心
2014年第23期1818-1821,共4页
Chinese Journal of Applied Clinical Pediatrics
关键词
中西医结合
小儿肺热咳喘口服液
肺炎支原体感染
临床表现
Combination of traditional Chinese medicine and western methods
Oral feirekechuan liqnid for children
Mycoplasma pneumoniae infection
Clinical manifestation
