摘要
目的 探讨国产盐酸哌罗匹隆治疗精神分裂症的疗效及安全性.方法 将60例精神分裂症患者随机分为两组,每组30例,分别口服盐酸哌罗匹隆和利培酮治疗,观察10周.于治疗前后采用阳性与阴性症状量表评定临床疗效,副反应量表评定不良反应.结果 治疗后两组阳性与阴性症状量表评分均较治疗前显著性下降（P＜0.05或0.01）,两组间各时点评分比较差异无显著性（P＞0.05）;不良反应均较轻微.结论 国产盐酸哌罗匹隆治疗精神分裂症安全、有效,耐受性好.
Objective To explore the efficacy and safety of domestic perospirone hydrochloride in the treatment of schizophrenia. Methods Sixty schizophrenia patients meeting diagnostic criteria were randomly assigned to perospirone hydrochloride and risperidone group （n= 30）, efficacies assessed with the Positive and Negative Syndrome Scale （PANSS） and adverse reactions with the Treatment Emergent Symptom Scale （TESS） before and after treatment. Results After treatment the PANSS scores of both groups lowered more significantly compared with pretreatment （P〈 0.05 or 0.01）, there were no significant intergroup differences in each time-point score （P〉0.05）. Adverse reactions of both groups were mild. Conclusion Domestic perospirone hydrochloride is safe, effective and well-tolerated in the treatment of schizophrenia.
出处
《临床心身疾病杂志》
CAS
2014年第6期31-33,共3页
Journal of Clinical Psychosomatic Diseases
