摘要
乙型肝炎e抗原(HBeAg)是由HBV-C基因区编码的一种非颗粒性的分泌型核壳蛋白,目前已证实HBeAg具有耐受原与免疫原双重作用,不参与乙型肝炎病毒(HBV)的复制、感染细胞及装配,但在慢性乙型肝炎宿主的免疫反应中发挥重要作用,其具体功能至今尚未完全明确。文章综述了HBeAg的生物学特征、免疫调节功能及其可能的作用机制和一般临床意义。
Hepatitis B e antigen（HBeAg）by HBV-C gene region encoding is a non-particulate, secreted nucleocapsid protein.At present has confirmed that HBeAg has dual roles oftoleragen and immunogen,is not involved in hepatitis B virus（HBV）replication,infected cells and assem-bly,but play an important role in the immune response of chronic hepatitis B Patients.However, its specific function has not yet entirely clear.This paper reviews the biological characteristics,im-mune function,possible mechanism and general clinical significance of HBeAg.
出处
《南昌大学学报（医学版）》
CAS
2014年第9期81-84,95,共5页
Journal of Nanchang University：Medical Sciences
基金
江西省自然科学基金(20111512070086)
关键词
乙型肝炎
e
抗原
乙型肝炎病毒
生物学特征
免疫调节
临床意义
hepatitis B e antigen
hepatitis B virus
biological characteristics
immunomodulators
clinical significance
