摘要
目的探讨隐匿性乳腺癌的临床表现、病理特征、治疗与预后。方法对5例隐匿性乳腺癌进行临床资料分析、组织形态学观察和免疫组化检测,并结合文献进行讨论。结果 5例隐匿性乳腺癌均表现为腋窝肿块,其中1例经MRI检查发现原发病灶,2例行乳腺癌改良根治术;2例行腋窝淋巴结清扫,1例行肿块扩大切除术。组织学分型:3例为浸润性导管癌,2例为混合型癌;淋巴结平均2.4枚可见转移。免疫组化示4例瘤细胞ER(+)、5例PR、CK7和E-cadherin(+),3例Her-2过表达。3例仅行腋窝肿块切除者,2例GCDFP-15(+),1例人乳腺球蛋白(+)。结论中、老年女性出现腋窝淋巴结转移性腺癌但未触及乳腺肿块时,应警惕隐匿性乳腺癌的可能。
Objective To study the clinical manifestation,pathological characteristics,treatment and prognosis of occult breast cancer.Methods The clinical data,morphological characteristics and immunohistochemical expression were analyzed in 5 cases of occult breast cancer,and discussed with review of the literature.Results Five cases of occult breast cancer showed axillary mass; one case was found the primary lesion by MRI.5 cases were treated by modified radical mastectomy （2 cases）,axillary lymph node dissection （2 cases） and extended lumpectomy （1 case）.Histological types in 3 cases were invasive ductal carcinoma,and 2 cases were mixed type carcinoma.The metastases were visible in average 2.4 lymph node.Immunohistochemistry showed that the tumor cells expressed ER （4 cases）,PR,CK7,E-cadherin and Her-2 in 3 cases.In 3 cases of axillary mass resection,2 cases expressed GCDFP-15 and 1 case expressed human mammaglobin.Conclusion In old women,when metastatic adenocarcinoma is found in axillary lymph node but not palpable breast masses,we should be vigilant for occult breast cancer.
出处
《诊断病理学杂志》
CSCD
北大核心
2014年第11期676-679,共4页
Chinese Journal of Diagnostic Pathology
关键词
隐匿性乳腺癌
转移
诊断
免疫组化
Occult breast cancer
Metastasis
Diagnosis
Immunohistochemistry
