摘要
目的 评价POAG患者的黄斑区脉络膜厚度,并与相同年龄段正常人群比较,分析其临床意义.方法 临床对照研究.共纳入POAG患者46例（46眼）和正常人50例（50眼）,采用频域OCT增强深度成像（EDI）测定中心凹下脉络膜厚度（SFCT）、距中心凹1 mm和3 mm处上、下、鼻、颞4个方位脉络膜厚度（S1CT、S3CT、I1CT、I3CT、N1CT、N3CT、T1CT、T3CT）.比较POAG患者与正常人黄斑区脉络膜厚度的差异,并分析POAG患者脉络膜厚度与年龄、IOP、眼部生物参数及视野平均缺损（MD）间的相关性.结果 POAG患者黄斑区脉络膜厚度分布趋势与正常人相似,均表现为黄斑中心凹下脉络膜（SFCT）最厚和鼻侧3 mm（N3CT）最薄;POAG患眼与正常人黄斑区脉络膜厚度差异无统计学意义;不同病程阶段POAG患者脉络膜厚度亦未观察到明显不同.POAG患者SFCT、I1CT、N1CT、N3CT及黄斑区平均脉络膜厚度与MD之间存在负相关（r=-0.509、-0.515、-0.495、-0.480、-0.478,P＜0.05）.结论 POAG患者和正常人黄斑区脉络膜厚度有类似分布特征,但且其黄斑区脉络膜厚度与正常人无明显差异.
Objective To evaluate choroidal thickness （CT） at various macular locations in primary open angle glaucoma （POAG） and compare it to normal eyes.Methods This was a cross-sectional study.Choroidal imaging at various macular locations was performed by enhanced depth imaging optical coherence tomography （EDI-OCT） in 46 eyes of 46 POAG patients and 50 eyes of 50 age-and sex-matched normal subjects.Measurements were taken of the subfovea,and at 1 and 3 mm to the fovea superiorly,inferiorly,temporally,and nasally.CT between POAG and normal subjects was compared.Correlations were calculated for the variation in CT relative to age,intraocular pressure （IOP）,MD and other ocular parameters.Results In both groups,the subfoveal CT was the thickest and 3 mm to the fovea nasally was the thinnest （P＜0.05）.CT in different stages of POAG showed no significant differences.Compared to normal subjects,CT at all macular locations in POAG eyes did not differ.In POAG eyes,CT at the subfovea,I1 mm,N1 mm,N3 mm and average CT showed negative correlations with MD （r=-0.509,-0.515,-0.495,-0.480,-0.478,P＜0.05）.Conclusion The CT at different locations of POAG eyes has a similar distribution compared to normal eyes.However,a significant difference between POAG and normal subjects has not been found.
出处
《中华眼视光学与视觉科学杂志》
CAS
2014年第10期579-583,共5页
Chinese Journal Of Optometry Ophthalmology And Visual Science
基金
国家自然科学基金面上项目（81371008）
