摘要
近来,个体差异造成降压药物不良反应的不同越来越受到重视,通过药物基因组学的研究,基因多态性已被认为是造成药物不良反应的首要原因。从基因水平揭示高血压药物不良反应的个体差异是一种有效的方法。本文综述了常用降压药物的不良反应与药物基因组学关系的研究进展,为高血压药物个体化应用于临床治疗应用提供参考依据。
Recently,increasingly importance has been attached to antihypertensive drug side effects caused by individual differences.According to the research of pharmacogenomics,genetic polymorphisms have been considered to be the primary cause of adverse drug reactions.From the level of gene revealed individual differences of adverse reactions to antihypertensive drugs is an effective method.This review summarized the research progress of the relationship between the adverse reactions to antihypertensive drugs and genetic polymorphisms.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2014年第10期1183-1188,共6页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
湖南省医药卫生科研计划课题(B2007173)
