摘要
目的:探讨β-七叶皂苷钠对多发性硬化(MS)患者血清中超敏C反应蛋白(HS-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-17(IL-17)水平及日常生活质量的影响。方法:采用免疫荧光干式定量法、ELISA法测定加用β-七叶皂苷钠治疗的54例MS患者(观察组)及53例未加用者(对照组)入院治疗前及治疗后血清中HS-CRP、TNF-α、IL-17水平。两组分别于治疗前后进行扩充神经功能残疾量表(EDSS)评分。结果:两组治疗前HS-CRP、TNF-α、IL-17水平比较,差异均无统计学意义(P>0.05);治疗后,两组均较治疗前明显降低(P<0.01),但观察组较对照组降低更显著(P<0.05)。两组治疗前EDSS评分比较,差异均无统计学意义(P>0.05),治疗14 d后比较差异有统计学意义(P<0.05)。结论:β-七叶皂苷钠可增强激素抑制HS-CRP、TNF-α、IL-17产生或释放的效果,进一步降低MS患者机体内炎症反应程度,达到治疗MS及提高其日常生活质量的目的。
Objective： To explore the influence of β-aescine sodium on the serum levels of HS-CRP, TNF-α, IL-17 and the quality of life in patients with MS .Methods：Quantitative immuno-cytochemistry and ELISA methods were used to determine the serum levels of HS-CRP, TNF-α, IL-17 in 54 MS patients treated with basic treatment and β-aescine sodium （ observation group ） and 53 MS patients treated without β-aescine sodium （ control group ） before and after treatment . The two groups before and after treatment were evaluated with extended neurological disability scale （EDSS） score respectively.Results：There was no significant difference of the levels of HS-CRP, TNF-α, IL-17 between observation group and control group .All the levels of HS-CRP, TNF-α, IL-17 decreased after treatment （ P〈0 .01 ） , but observation group decreased much more than control group （ P〈0 .05 ） .There was no significant difference of EDSS scores between observation and control groups before treatment （P〉0.05）, but EDSS scores of two groups were different after treatment （P〈0.05）.Conclusion：β-aescine sodium could enhance the effects of hormone on in-hibiting the production and release of HS-CRP, TNF-α, IL-17, further reduce inflammatory reac-tion in patients with MS , and improve the quality of life .
出处
《河南医学研究》
CAS
2014年第9期11-14,共4页
Henan Medical Research
关键词
多发性硬化
Β-七叶皂苷钠
超敏C反应蛋白
扩充神经功能残疾量表
multiple sclerosis β-aescine sodium high sensitivity C reactive protein extended neurological disability scale
