摘要
目的:探讨复合凝乳酶胶囊治疗慢性萎缩性胃炎的机制。方法:首先制备大鼠CAG模型,设置模型对照组、正常对照组、复方凝乳酶胶囊观察组,三组实验作对比,观察大鼠胃液中的胃蛋白酶的活性、游离酸及胃黏膜上的病理组织学改变。结果:复合凝乳酶胶囊治疗30 d后,与模型对照组作对比,胃液中的游离酸含量升高明显,胃液游离酸明显升高(P<0.05),胃蛋白酶的活性同时增强,差异无统计学意义(P>0.05);胃黏膜上皮细胞也由异常的细胞形态明显改善,胃黏膜上的炎细胞数量也明显的减少,胃黏膜由较薄的病理状态逐渐增厚至正常状况。结论:复合凝乳酶胶囊能明显的改善慢性萎缩性胃炎的病理状态。
Objective：To explore and discuss the mechanism of Gastropylor Complex Capsules in the treatment of chronic atrophic gastritis. Method：Rat CAG model was prepared firstly,and then three experienmental groups inclusive of model control group,normal control group,and Gastropylor Complex Capsule group were set for comparison.Observations were made on the activity of pepsin and free acid in the gastric juices and the histopathological changes on gastric mucosa.Result：After 30-day treatment of castropylor complex capsules,the content of free acid in gastric juice, when compared with that of model group,increased more significantly,which showed there was a significant increase of free acid in gastric juice（P〈0.05）. In the meanwhile,the activity of pepsin also enhanced,though with no significant difference（P〉0.05）.Gastric mucosa epithelial cells evidently improved from abnormal cell morphology,the number of inflammatory cells on gastric mucosa reduced obviously,and pathological state on the gastric mucosa changed from thinner to normal by gradually thickening.Conclusion：Gastropylor Complex Capsules can significantly improve the pathological state of chronic atrophic gastritis.
出处
《中外医学研究》
2014年第31期21-22,共2页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
复合凝乳酶胶囊
胃炎
萎缩性
机制
Gastropylor Complex Capsules
Gastritis
Atrophic
Mechanism
