摘要
目的： 探讨安神抗癫方联合天马西平及丙戊酸钠治疗癫痫的疗效及对抗氧自由基和炎症反应影响. 方法： 将92例癫痫患者随机按数字表法分为对照组和观察组各46例.对照组服用卡马西平片,0.2～1.0 g·d^-1,分3次口服;丙戊酸钠片,0.4～1.6 g·d^-1,分3次口服;观察组在对照组治疗的基础上加用安神抗癫方加减治疗.两组疗程均为6个月.进行治疗前后癫痫发作情况及生活质量量表评价;进行治疗前后长程脑电图（EEG）检测;检测治疗前后血清肿瘤坏死因子-α（TNF-α）、白介素-1β（IL-1β）、丙二醛（MDA）和超氧化物歧化酶（SOD）水平. 结果： 经有序资料卡方检验,观察组临床疗效优于对照组（P〈0.05）;治疗后观察组癫痫发作情况评分低于对照组,生活质量评分高于对照组（P〈0.01）;治疗后观察组痫样放电例数少于对照组（P〈0.05）;治疗后观察组血清TNF-α,IL-1和MDA水平低于对照组（P〈0.01）,血清SOD水平高于对照组（P〈0.01）. 结论： 安神抗癫方联合卡马西平及丙戊酸钠治疗癫痫减少了癫痫发作频率,提高了生活质量,其作用机制可能与清除氧自由基,减轻炎性反应有关.
Objective： To observe the curative efficacy of Anshen Kangdian decoction combined with carbamazepine and Sodium valproate acid and to discuss its influence on anti oxygen free radicals and inflammatory reaction in treating epilepsy. Method： Ninety-two patients were randomly divided into control group （46 cases） and observation group （46 cases） by random number table. Patients in control group received 0.2-1.0 g carbamazepine tablets orally at 3 times daily and 0.4-1.6 g sodium valproate tablets orally at 3 times daily. Based on the treatment of control group, patients in observation group added modified Anshen Kangdian decoction treatment. Patients in both group received 6 month periods of treatment. Seizure situation and quality of life were evaluated before and after the treatment. Besides, a long-term electroencephalogram test was conducted. Levels of serum tumor necrosis factor-α （TNF-α）, interleukin-1β（IL-1β）, malondialdehyde （MDA） and superoxide dismutase （SOD） were detected before and after the treatment. Result： The clinical curative effect of control group was superior to that of observation group （P〈0.05） by the chi-square test order data. Scoring of epileptic seizures in observation group was less than that in control group, while the quality of life score in observation group was higher than that in control group after treatment （P〈0.01）. The number of epileptiform discharge cases in observation group was less than the number of control group （P〈0.05）, while the number of epileptiform discharge declined or disappeared in observation group was more than the number of control group after treatment （P〈0.05）. Levels of serum TNF-α, IL-1 and MDA in observation group were inferior to those in control group （P〈0.01）, while serum SOD level of observation group was higher than that of control group （P〈0.01）. Conclusion： Therapy of Anshen Kangdian decoction combined with carbamazepine tablets and Sodium valproate acid can reduce seizure fr
出处
《中国实验方剂学杂志》
CAS
北大核心
2014年第23期201-204,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
济南市卫生局科技计划项目(2013-42)
关键词
癫痫
安神抗癫方
中西医结合疗法
氧自由基
炎性反应
epilepsy
Anshen Kangdian decoction
combined therapy of traditional Chinese and western medicine
oxygen radical
inflammatory reaction
