摘要
目的观察麝香保心丸治疗肺源性心脏病(肺心病)合并冠心病的疗效。方法将肺心病合并冠心病患者分为2组:对照组给予常规治疗,治疗组在常规治疗基础上给予麝香保心丸治疗,观察2组初次住院期间治疗14 d时的疗效,治疗6个月后2组人均住院时间,缺血性心电图指标的改善情况,肺心病患者自我评估测试问卷(CAT)评分、左室射血分数(LVEF)、左心室短轴缩短率(LVFS)、二尖瓣快速充盈期与心房收缩期血流速度比(E/A)、平均肺动脉压(m PAP)、血沉(ESR)、红细胞压积(PCV)、纤维蛋白原(FIB)及超敏C反应蛋白(hs-CRP)的改善情况,同时观察用药后患者的耐受性及不良反应发生情况。结果 2组急性住院期间疗效比较差异无统计学意义;但观察6个月后,治疗组住院时间显著短于对照组(P<0.05),缺血性心电图改善情况、CAT评分、LVEF、LVFS、E/A、m PAP以及ESR、FIB、hs-CRP改善情况均优于对照组(P均<0.05),且患者临床耐受性良好,未见明显毒副作用。结论麝香保心丸可以改善肺心病合并冠心病患者的CAT评分和心功能,缩短住院时间。
Objective It is to observe the curative effect of Shexiang Baoxin pill（SBP） on cor pulmonale combined with coronary artery disease （CAD）.Methods The patients with cor pulmonale combined with CAD were randomly divided into 2 groups：the control group was given normal therapy,and the treatment group given SBP on the basis of normal therapy.Making a comparison between the two groups about the medicine~ curative effect in the first 14 days they were in hospital.To observe the two groups＇per hospitalization time after 6 months treatment,the situation of the chemic electrocardiographic index,COPD self assessment questionnaire （CAT） scores,ultrasonic cardiogram index of left ventricular ejection fraction （LVEF）,left ventricular fractional shortening （LVFS）,mitral valve rapid filling phase and atrium systolic velocity ratio （E/A）,situation of the mean pulmonary arterial pressure （mPAP）,erythrocyte sedimentation rate of the hemorheology （ESR）,packed cell volume （PCV）,fibrinogen （FIB） and the high sensitive C-reactive protein （hs-CRP）.At the same time,observed the tolerability,safety and adverse reaction after taking the medicine.Results There was no significant difference in the curative effect during acute hospitalization stage between the two groups,but after 6 months,the hospitalization time of treatment group was significantly shorter while the improvements of electrocardiographic index,CAT scores,LVEF,LVFS,E/A,mPAP and ESR,FIB,hs-CRP were better than that of control group （P 〈 0.05）.Moreover,SBW had well clinical tolerability and no obvious toxic side effect.Conclusion SBW can improve the CAT score and heart function of the patients with cor pulmonale combined with coronary artery disease and shorten the time of hospitalization.
出处
《现代中西医结合杂志》
CAS
2015年第1期33-36,共4页
Modern Journal of Integrated Traditional Chinese and Western Medicine
