摘要
目的探讨血浆脂联素、糖化血红蛋白(HbA1c)、血脂及体质量指数(BMI)在糖调节受损(IGR)人群、2型糖尿病(T2DM)患者中的作用。方法选取重庆市区自愿参加体检的人群分为3组:T2DM组145例、IGR组128例及对照组(NGT组)160例,检测空腹血浆脂联素,同时测定HbA1c、胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)以及测量身高、BMI,进行比较分析。结果T2DM组HbA1c、TC、TG、LDL-C、BMI均高于对照组,而脂联素、HDL-C低于对照组,差异有统计学意义(P<0.05);IGR组HbA1c、TC、TG、LDL-C、BMI均高于对照组,而脂联素、HDL-C低于对照组,差异有统计学意义(P<0.05):T2DM组HbA1c、TC、TG、LDL-C、BMI均高于IGR组,而脂联素、HDL-C低于IGR组,差异有统计学意义(P<0.05)。结论从糖耐量正常再到IGR到T2DM发生、发展过程中,随着BMI的升高,血浆脂联素水平逐渐降低,而HbA1c、TC、TG、LDL-C却逐渐升高,因此,积极控制BMI可以调节血浆脂联素水平,将对防治IGR、糖尿病、血脂紊乱具有非常重要的作用。
Objective To investigate the difference of adiponectin ,glycosylated hemoglobin （HbA1c） ,blood lipid and body mass index（BMI）in individuals with impaired glucose regulation（IGR） and type 2 diabetes mellitus （T2DM ） ,and to predict their effect in development of IGR 、T2DM .Methods Medical examination objects were selected and divided into three groups ：145 patients with newly diagnosed T2DM group ,128 patients with impaired glucose regulation（IGR group） ,160 individuals with normal glucose tol‐erance （NGT group ,as control） .Fasting adiponectin ,HbA1c ,total cholesterol （TC ） ,triglyceride （TG ） ,low density lipoprotein （LDL‐C） ,high density lipoprotein cholesterol（HDL‐C） were determined .We measured body height ,body weight to compute body mass index（BMI） .Results The levels of HbA1c ,TC ,TG ,LDL‐C ,BMI were significantly higher in T2DM group than those in NGT group（P〈 0 .05） ,the levels of HDL‐C and adiponectin were more declined in T2DM group than those in NGT group （P〈0 .05） .The levels of HbA1c ,TC ,TG ,LDL‐C ,BMI were significantly higher in IGR group than those in NGT group（P〈 0 .05） ,the levels of HDL‐C and adiponectin were more declined in IGR group than those in NGT group （P 〈 0 .05） .The levels of HbA1c , TC ,TG ,LDL‐C ,BMI were significantly higher in T2DM group than those in IGR group（P 〈 0 .05） ,the levels of HDL‐C and adi‐ponectin were more declined in T2DM group than those in IGR group （P 〈 0 .05） .Conclusion During the course of disease from NGT to IGR to T2DM ,plasma adiponectin levels are decreasing ,however HbA1c ,TC ,TG ,LDL‐C are increasing gradually while BMI were increasing .Therefore it has very important effect and significance in controlling BMI and plasma adiponectin levels to pre‐vent and cure IGR ,T2DM and plasma lipid disorder .
出处
《重庆医学》
CAS
CSCD
北大核心
2014年第31期4188-4189,4192,共3页
Chongqing medicine
基金
国家自然科学基金资助项目(81460168
30570744)
遵义医学院附属医院中青年科研启动基金[院字(2010)03号]
遵义医学院博士启动基金(F-574)
关键词
糖尿病
2型
脂联素
血红蛋白A
糖基化
人体质量指数
糖调节受损
血脂
diabetes mellitus, type 2
adiponectin
hemoglobin A, glycosylated
body mass index
impaired glucose regulation
blood lipid
