摘要
以胆固醇和卵磷脂二元脂质体为研究模型,采用原子力显微镜显微技术,结合基本的热力学、静电力学与胶体科学原理,从微观成像的结果追溯和推测更微观层面上的作用机制,对金属阳离子对脂质体结构稳定性形态学特征进行了初步分析。研究发现,胆固醇的含量对脂膜的流动性和稳定性有着明显的影响,而金属阳离子可与磷脂分子极性头基发生作用,从而影响到脂质体的组装能力以及脂质体胶体系统的热力学稳定性。
This article showed primary study and analyses on the impacts done by the metal cations to the stability of liposomes which are made of cholesterol and lecithin. Using images given by atomic force mi- croscope, the interaction mechanism in nanoscale was investigated and conducted by methods combining basic principles of thermodynamics, electrostatics and colloid science. The study illustrated that the pro- portion of cholesterol significantly influenced the fluidity and stability of the lipid membrane. Meanwhile, it also indicated that the cations could influence these liposomes both on the ability of assembling them- selves and on the thermodynamic stability by interactions with polar heads of the phospholipid molecules.
出处
《动物医学进展》
CSCD
北大核心
2014年第11期44-48,共5页
Progress In Veterinary Medicine
基金
国家自然科学基金项目(11202170)
西北农林科技大学大型仪器设备新功能开发项目(dysb130105)
西北农林科技大学大学生创新训练计划项目(2201210712209)
关键词
脂质体
阳离子
结构稳定性
原子力显微镜
liposome
cation
structural stability
atomic force microscopy
