摘要
p53蛋白作为细胞内重要的肿瘤抑制因子,通过复杂的信号转导网络调节细胞生理活动,维护基因组的稳定性与完整性.p53网络能对细胞遭遇的一系列应激信号(如DNA损伤、致癌基因激活和端粒受损等)做出响应,启动DNA修复、细胞周期阻滞、细胞衰老或凋亡等来避免基因组缺陷的复制和遗传.p53蛋白浓度在细胞应激响应过程中呈现脉冲、开关等动力学行为,具有丰富的非线性特征.本文旨在综述p53网络动力学领域的最新进展,揭示细胞DNA损伤响应过程中p53动力学与功能之间的潜在联系.
The p53 protein is an important tumor suppressor that modulates many physiological activities of the cell and maintains the stability and integrity of the genome. p53 is located at the center of a complicated signaling network. The p53 network can respond to a wide variety of stress including DNA damage, oncogene activation and telomere erosion. Depending on the severity of DNA damage, p53 may induce DNA repair/cell cycle arrest, senescence, or apoptosis to avoid the replication and propagation of the genomic defects to daughter cells. The concentration of p53 exhibits several types of dynamics such as pulsatile and switch-like behaviors. There exist rich nonlinear properties in the p53 dynamics. In this review, we focus on the latest progress in the field of p53 dynamics, and clarify the underlying connection between p53 dynamics and its biological functions in the DNA damage response.
出处
《中国科学：物理学、力学、天文学》
CSCD
北大核心
2014年第12期1311-1318,共8页
Scientia Sinica Physica,Mechanica & Astronomica
基金
国家重点基础研究发展计划(编号:2013CB834104)
国家自然科学基金(批准号:11175084,11204126,31361163003)资助项目
