摘要
正常干细胞与缺氧关系密切,在不同阶段有不同的糖代谢特点,主要以糖酵解为主,既可以快速产生ATP,又可以减少ROS产生,以保证干细胞的稳态。肿瘤干细胞线粒体功能障碍,决定了它也是以糖酵解代谢为主。微环境中的氧和葡萄糖浓度都影响着肿瘤干细胞的干性变化,并且糖酵解抑制剂显示了显著的杀伤肿瘤干细胞的能力,这是提高肿瘤疗效的方向之一。
Normal stem cells,which harbor different glucose metabolism properties during pro- liferation and differentiation,reside in hypoxic niches,and depend mostly on glycolysis featuring rapid generation of ATP and reduction of ROS production,to maintain its homeostasis. Due to the mitochondrial dysfunction,cancer stem cells （CSCs） exhibit high glycolytic activity. Oxygen concentration and glucose in the microenvironment exert a profound effect on stemness, and in- hibitors of glycolysis significantly eliminate CSCs with potential benefits in cancer treatment.
出处
《肿瘤学杂志》
CAS
2014年第11期947-950,共4页
Journal of Chinese Oncology
基金
国家自然科学基金项目(81272641
81071872)
广东省科技计划项目(2011B061300069)
关键词
肿瘤干细胞
糖代谢
糖酵解
氧化磷酸化
cancer stem cell
glucose metabolism
glycolysis
oxidative phosphorylation
