摘要
目的建立药用卤化丁基橡胶塞中可提取硫的检测方法。方法以微波萃取的方式对样品进行前处理,采用高效液相色谱法,以Agilent XDB-C18为色谱柱,甲醇-水（95∶5）为流动相,流速：1.0mL·min^-1,检测波长：264nm。结果硫的检测线性范围为1～10μg·mL^-1（r=0.999 6）;平均回收率为95.2%,RSD=2.3%（n=9）。结论该方法经方法学验证,可用于考察药用卤化丁基橡胶塞中可提取硫的含量。
Objective To establish a method for determining sulphur extracted from the medicinal halogenated butyl rubber.Methods The samples were preprocessed by microwave extraction.The column Agilent XDB-C18 was used for HPLC.The mobile phase consisted of methanol-water（95∶5）.The flow rate was 1.0 mL· min^-1.The detection wavelength was 264 nm.Results The linearity range for extracted sulphur was from 1to 10μg·mL^-1（r=0.999 6）.The average recovery assay was 95.2%,and the RSD was 2.3%（n=9）.Conclusion The method is simple,rapid,accurate,and can be used to determine sulphur extracted from the medicinal halogenated butyl rubber.
出处
《中国药事》
CAS
2014年第11期1257-1260,共4页
Chinese Pharmaceutical Affairs
关键词
药包材
卤化丁基橡胶塞
硫化剂残留检测
可提取硫检测
高效液相色谱法
pharmaceutical packaging material
halogenated butyl rubber
detection of the residual vulcanizing agent
detection of extractable sulphur
HPLC
