摘要
目的：探讨乌司他丁对脓毒症患者降钙素原（PCT）水平的影响及临床意义。方法将2013年3-12月收治的60例脓毒症患者随机分为治疗组（31例）和对照组（29例），治疗组给予注射用乌司他丁1万U/（kg·d），对照组给予同等剂量生理盐水，均24h持续静脉微量泵入，连续7d。两组患者均于用药前1d和用药7d后清晨抽取外周血检测PCT水平，并观察28 d住院病死率。结果治疗组用药7 d后PCT水平低于同期对照组，28 d住院病死率低于对照组，差异均有统计学意义（P〈0.05）。结论乌司他丁能降低脓毒症患者体内PCT水平，拮抗炎性反应，降低28 d住院病死率。
Objective To explore the curative effect and clinical significance of ulinastatin on procalcitonin （PCT） in patients with sepsis. Methods A total of 60 patients with sepsis,who were received from March to December of 2013,were ran-domly divided into treatment group（n=31） and control group（n=29）. The treatment group was injected with ulinastatin with the dosage of 10 000 U/（kg·d）,while the control group received normal saline with the same dose of the treatment group,24 h con-tinuously intravenous macro-pump for 7 d. Peripheral blood was withdrawn in both groups 1 d before administration and 7 d after administration to measure the PCT level,and the 28 d hospital fatality rate was observed. Results The PCT level 7 d after admin-istration in the treatment group was lower than that in the control group in the same period ,and the 28 d hospital fatality rate in the treatment group was lower than that in the control group, the differences between the two groups all had statistical significance（P〈0.05）. Conclusion Ulinastatin can reduce PCT level in patients with sepsis,inhibit inflammation response and decrease 28 d hospital fatality rate.
出处
《现代医药卫生》
2014年第22期3385-3387,共3页
Journal of Modern Medicine & Health
关键词
糖蛋白类
脓毒症
炎症
降钙素
死亡率
预后
Glycoproteins
Sepsis
Inflammation
Calcitonin
Mortality
Prognosis
