摘要
建立大鼠血浆中曲马多(1)的高效液相-荧光检测法,考察大鼠肌注市售1注射液(参比制剂)、自制的1脂质体和1多囊泡脂质体的药动学行为。上述3种制剂主要药动学参数分别为:tmax(0.69±0.19)、(2.06±0.68)和(4.29±1.63)h,cmax(5.08±0.86)、(3.02±0.48)和(2.27±0.24)μg/ml,AUC0→t(37.34±9.77)、(46.76±15.14)和(67.10±24.53)μg·h·ml-1。1脂质体和1多囊泡脂质体的相对生物利用度分别为125.2%和179.7%。结果显示,1多囊泡脂质体的缓释特征比1脂质体更显著。
An HPLC method with fluorescence detection was established for the determination of tramadol （1） in rat plasma.The pharmacokinetic behaviors of the self-made liposomes （1-Lip） and multivesicular liposomes （1-MVLs） after im injection to SD rats were investigated with the commercial injection as the reference.The main pharmacokinetic parameters of the injection,1-Lip and 1-MVLs were as follows：tmax （0.69±0.19）,（2.06±0.68） and （4.29±1.63）h,Cmax （5.08±0.86）,（3.02±0.48） and （2.27±0.24）tg/ml,AUC0→t （37.34±9.77）,（46.76±15.14） and （67.10± 24.53） μg·h·ml-1,respectively.The relative bioavailabilities of 1-Lip and 1-MVLs were 125.2 ％ and 179.7 ％.Compared with 1-Lip,the sustained-release property of 1-MVLs was more pronounced.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2014年第11期1053-1056,共4页
Chinese Journal of Pharmaceuticals
基金
广东省医学科研基金(A2012159)
