摘要
锌及其配合物具有类胰岛素作用,并且生物兼容性强,稳定性好及体内外降糖作用明显。自发现锌化合物具有类胰岛素作用以来,锌配合物及其抗糖尿病作用受到国内外学者的热切关注。锌在体内参与糖类和脂质代谢等生理生化过程,锌及其配合物抗糖尿病作用机制主要包括直接参与胰岛素合成、抗氧化、参与调控酪氨酸蛋白磷酸化酶和提高免疫功能等。具有Zn(N2O2)配合型的锌配合物有较好的类胰岛素作用,其中,L-茶氨酸锌是具有天然配基的一类锌配合物,对糖尿病模型小鼠有显著降糖作用,且化学性质稳定,体内吸收快,口服无副作用。本文就锌及其配合物在抗糖尿病应用方面的进展进行综述。
Zinc and its compounds with insulin-like effects have been found to own such properties as strong bio-compatibility,good stability and remarkable hypoglycemic effect. Since the discovery of their insulin-like function,zinc compounds and their anti-diabetic effects have been a geobal focus of research. Zinc ion is involved in physiological and biochemical processes in vivo,such as in carbohy-drate and lipid metabolism. The mechanism of zinc and zinc complexes in anti-diabetic activity are sum-marized in this article,including direct participation in insulin synthesis,antioxidation,involvement in the regulation of tyrosine protein phosphatase,and improving immunity. Zinc complexes with Zn（N2O2 ）have remarkable insulin-like effects. Particularly,the L-theanine-zinc compound,which is a class of zinc com-plexes with natural ligands,has also been found to show significant hypoglycemic effect in an in vivo experiment on KK-Ay mice,have stable chemical properties,be absorbed fast in vivoand be non-toxic with oral administration during model animal experiments. This paper reviews the progress in research on relationships between zinc and its complexes and the anti-diabetic effect.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
2014年第5期774-778,共5页
Chinese Journal of Pharmacology and Toxicology
关键词
L-茶氨酸
类胰岛素活性
糖尿病
锌配合物
L-theanine
insulinomimetic activity
diabetes mellitus
zinc compound
