摘要
目的：探讨上海郊区自然人群餐后2h血糖水平与肱踝脉搏波传导速度（BaPWv）的相关性。方法：在上海市嘉定区选取2519名居民，对其进行问卷调查、体格检查、血和尿的生化检查以及BaPWV的检测，按餐后2h血糖值四分位分组，分析餐后2h血糖水平与BaPWV的相关性，以及动脉硬化患病情况。结果：①随着餐后2h血糖水平的升高，4组BaPWV值总体呈显著增高趋势，分别为（1429．85±401．90）、（1425．70±383．31）、（1594．77±403．23）、（1709．11±399．05）cm／s；动脉硬化患病率依次升高，分别为15．40％、16．42％、27．97％、40．57％，组间趋势明显（趋势P〈0．0001）。②Pearson相关分析显示，餐后2h血糖水平与BaPWV正相关忙0．25514，P〈0．0001）；多元回归分析显示，餐后2h血糖是BaPWV的独立危险因素（β=0．0906，P=0．0008）。③多元Logistic回归分析显示．在校正性别、年龄、体质量指数（BMI）、腰围、收缩压、舒张压、血清三酰甘油（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL—C）、空腹胰岛素、空腹血糖、糖化血红蛋白（HbAlc）后，与餐后2h血糖值下四分位组比较，第3、4分位组动脉硬化的患病风险逐渐升高，比值比（OR）[95％可信区间（CI）1分别为1．669（1．098～2．539）、1．713（1.094-2．682），趋势P=0．0036。结论：上海市嘉定区人群中，餐后2h血糖是动脉硬化的独立危险因素。
Objective To study the association of postprandial blood glucose level with brachial ankle pulse wave velocity （BaPWV） in middle-aged and elderly population. Methods Two thousand five hundred and nineteen subjects aged 40 years or older from Jiading district, Shanghai were recruited to undergo questionnaire interview, anthropometric measurements, biochemical evaluation and BaPWV measurement. After excluding subjects with missing BaPWV or postprandial data, two thousand three hundred and seventy-seven subjects were enrolled in the final analysis（989 men and 1 388 women）. The association of BaPWV and postprandial blood glucose level,as well as the prevalence of arteriosclerosis, was analyzed by multiple Logistic regression analysis according to the four quartiles of postprandial blood glucose level. Results From postprandial blood glucose level quartile 1 to quartile 4, the average BaPWV is （1 429.85±401.90）, （1 425.70±383.31）, （1 594.77±403.23）, （1 709.11±399.05） cm/s, respectively; The prevalence of arteriosclerosis is 15.40%, 16.42%, 27.97%, 40.57%, accordingly. The trend among groups is significant （P〈0.0001）. Postprandial blood glucose level is positively correlated with BaPWV （r=0.25514, P〈0.0001）. Postprandial blood glucose level is an independent risk factor of BaPWV （β=0.0906, P=0.0008）. After adjusting for sex, age, body mass index （BMI）, waist circumstance, systolic blood pressure （SBP）, diastolic blood pressure （DBP）, triglycerides （TG）, total cholesterol （TC）, low- density lipoprotein cholesterol （LDL-C）, high-density lipoprotein cholesterol （HDL-C）, fasting insulin, fasting blood glucose level, glycated hemoglobin Alc （HbAlc）, compared with the quartile 1, the risk of prevalence of arteriosclerosis in subjects with postprandial blood glucose level of quartile 3 and quartile 4 rise significantly. The odds ratio and 95% confidence interval is 1.669 （1.098-2.539）, 1.713 （1.094-2.682）, respectively（P=0.003 6）. Conclus
出处
《内科理论与实践》
2014年第5期328-333,共6页
Journal of Internal Medicine Concepts & Practice
基金
国家自然科学基金项目(项目编号:81170739)
关键词
餐后2小时血糖
肱踝脉搏波传导速度
动脉硬化
Postprandial blood glucose
Brachial ankle pulse wave velocity
Arteriosclerosis
