摘要
目的分析臂踝脉搏波传导速度（baPWV）在老年人群中的分布特征及其影响因素，从而指导老年人群动脉硬化疾病的早期预防。方法随机选取江苏盛泽地区19个农村共927例老年居民，通过标准化的问卷调查及体格检查采集年龄、性别、身高、体重、腰围、臀围及血压等指标，通过全自动生化分析仪检测胆红素、肌酐、尿酸、空腹血糖、血脂等生化指标，通过动脉硬化检测装置采集baPWV。结果年龄、收缩压、心率、胆红素、肌酐、尿酸、三酰甘油、总胆固醇及baPWV指标在老年男女性之间差异有统计学意义（P均〈0．05）。baPWV随年龄增加而上升，女总体baPWV高于男（P〈0．01）。血压（r=0．36、0．59，P〈0．001）、年龄（r=0．26、0．30，P〈0．001）、心率（r=0．30、0．33，P〈0．001）与baPWV相关性较强，尿酸（r=0．12、0．21，P〈0．01）与baPWV相关性较弱，总胆固醇（r=0．09、0．11，P〈0．05）与baPwV相关度极低。多元线性逐步回归分析显示收缩压、心率及年龄均为baPWV的影响因素，其中收缩压对baPwV的影响最大（β〉0．5，P〈0．001）。结论老年人随着年龄增长，baPWV呈上升趋势，要加强老年人群尤其是女性老年人群baPWV的监测，控制血压尤其是降低收缩压能一定程度减缓动脉硬化的发展。
Objective To analyze the distribution characteristics and influencing factors of brachial-ankle pulse wave velocity （baPWV） in elderly population in order to direct the early diagnosis and prevention of arteriosclerosis in the elderly. Methods A total of 927 cases of elderly residents were randomly selected from 19 villages in Shengze area, Jiangsu Province. The indexes such as age, gender, height, weight, waist circumference, hip circumference and blood pressure were collected through standardized questionnaire and physical examination. The biochemical indicators including serum bilirubin, creatinine, uric acid, fasting blood glucose and blood lipids were measured, and baPWV was tested by a ut0matic arteriosclerosis measurement system. Results The differences in age, systolic blood pressure, heart rate, serum bilirubin, creatinine, uric acid, triglycerides levels and baPWV were statistically significant between the male and female （all P〈0. 05）. BaPWV rised with the increase of age. Overall, baPWV was faster in the female than in male （P〈0. 01）. Blood pressure （r=0.36,0. 59, P〈0. 001）, age （r=0. 26,0.30, P〈0. 001） and heart rate （r=0.30,0. 33, P〈 0. 001） were correlated with baPWV, while uric acid had a correlation with baPWV （r=0. 12,0. 21, P〈0. 01）. A correlation was found between total cholesterol and baPWV （r=0. 09,0.11, P〈0. 05） ; Multi-variable linear stepwise regression analysis showed that systolic blood pressure, heart rate and age were the influencing factors for baPWV, of which systolic blood pressure had the greatest influence on baPWV （β〉0. 5, P〈0. 001）. Conclusions With the increase of age, the baPWV shows rising trend. The monitor of baPWV may be useful in the elderly, especially in females. Blood pressure control, especially the control of systolic blood pressure can slow the progression of atherosclerosis.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2016年第3期243-246,共4页
Chinese Journal of Geriatrics
基金
新型临床诊疗技术攻关项目（BL2014085）
江苏省卫生厅面上项目（H201402）
