摘要
目的:观察地特胰岛素联合门冬胰岛素治疗2型糖尿病(T2DM)的临床疗效和安全性,探讨其临床应用价值。方法:将160例T2DM患者随机分为两组,分别应用地特胰岛素联合门冬胰岛素(地特胰岛素组,80例)和甘精胰岛素联合门冬胰岛素(甘精胰岛素组,80例)治疗12周。观察两组治疗前后空腹血糖(FBG)、餐后2 h血糖(2hBG)、糖化血红蛋白(HbA1c)的变化水平,计算胰岛B细胞功能(HOMA-B)和胰岛素抵抗指数(HOMA-IR),记录胰岛素用量和低血糖发生率等。结果:治疗后两组患者FBG、2hBG和HbA1c与治疗前比较均明显降低(P<0.01),但组间比较差异无统计学意义(P>0.05);治疗后HOMA-B较治疗前明显升高(P<0.01),HOMA-IR明显降低(P<0.01),但组间比较差异无统计学意义(P>0.05);在血糖控制达标时间、胰岛素平均日剂量和低血糖发生率方面组间比较差异均无统计学意义(P>0.05)。结论:地特胰岛素能有效控制血糖水平,明显改善患者胰岛B细胞功能,和甘精胰岛素联合门冬胰岛素疗效和安全性相似。
OBJECTIVE： To observe the clinical efficacy and safety of insulin detemir combined with insulin aspart in the treat- ment of type 2 diabetes mellitus （T2DM）, and to evaluate the clinical value of them. METHODS： 160 T2DM patients were random- ized into 2 groups, as insulin detemir group （insulin detemir combined with insulin aspart, 80 cases） and insulin glargine group （insu- lin glargine combined with insulin aspart, 80 cases）. Treatment course of 2 groups lasted for 12 weeks. The levels of FBG, 2h postpran- dial glucose （2hBG） and HbAlc were observed before and after treatment; islet B cell function （HOMA-B） and insulin resistance （HOMA-IR） were also calculated. The insulin dosage and the incidence of hypoglycemia were also recorded. RESULTS： Compared with before treatment, the levels of FBG, 2hBG and HbA^c decreased significantly after treatment （P〈0.01） ; there was no statistical significance between 2 groups （P〉0.05）. HOMA-B was increased significantly （P〈0.01） while HOMA-IR was decreased significant- ly （P〈 0.01 ） ; there was no statistical significance between 2 groups （P〉 0.05）. The time of blood glucose control, average daily dos- age of insulin and the incidence of hypoglycemia had no statistical significance between 2 groups （P〉0.05）. CONCLUSIONS： Insulin detemir combined with insulin aspart can control the blood glucose effectively and improve the islet B cell function obviously, which is similar to insulin glargine combined with insulin aspart in clinical efficacy and safety.
出处
《中国药房》
CAS
CSCD
2014年第38期3608-3610,共3页
China Pharmacy
基金
广西玉林市科学研究与技术开发计划项目(No.12067007)
