摘要
目的比较口服药控制不佳的2型糖尿病患者加用1天1次地特胰岛素或甘精胰岛素治疗的有效性、安全性及体重的变化。方法选取60例口服药控制不佳的2型糖尿病患者,保持原有口服药方案不变,按随机数字表法随机分为两组,每组30例,一组加用1天1次睡前地特胰岛素注射(治疗组),一组加用甘精胰岛素(对照组),治疗期为12周,比较两组治疗前后空腹血糖(FBG)、糖化血红蛋白(HbA1c)、体重的变化及低血糖的发生。结果两组的HbA1c和FBG同治疗前相比均有明显下降(P<0.01),但组间比较差异均无统计学意义(P>0.05);与对照组相比,治疗组体重增加少,差异有统计学意义(P<0.01);两组各发生1例低血糖,发生率均为3.3%。结论口服药治疗不佳的2型糖尿病患者,加用1天1次地特胰岛素治疗同甘精胰岛素相比,有效性、安全性相似,但体重增加少。
Objective To compare efficacy、safety and change in weight after once-daily insulin detemir or insulin glargin added to oral antidiabetic drugs in poorly controlled type 2 diabetes patients.Methods 60 type 2 diabetic patients with poor glycemic control by oral antidiabetic drugs were randomly divided into the A group(n = 30,to receive once-daily bedtime insulin detemir injection)and the B group(n = 30,to receive once-daily bedtime insulin glargin injection).The observation lasted for 12 weeks.The parameters measured before and after treatment included fasting plasma glucose(FPG)、HbA1c and weight.Hypoglycemia was also noted.Results After 12 weeks'treatment,FPG and HbA1c were both significantly decreased than before(P < 0.01),but no statistical difference between two groups(P > 0.05).The increased value of weight was less in A group than in B group(P < 0.01).The incidence of hypoglycemia was similar between two groups(3.3% vs 3.3%).Conclusion As compared to once-daily insulin glargin,Once-daily insulin detemir added to oral antidiabetic drugs in poorly controlled type 2 diabetes patients was similar on efficacy and safety,but was less in the weight gain.
出处
《实用医院临床杂志》
2010年第4期42-44,共3页
Practical Journal of Clinical Medicine
