摘要
目的:考察丙泊酚中/长链脂肪乳注射液与小剂量盐酸利多卡因注射液的配伍稳定性。方法:分别将盐酸利多卡因注射液0.25、0.5、1 ml(含盐酸利多卡因5、10、20 mg)加入丙泊酚中/长链脂肪乳注射液20 ml中,考察6 h内配伍溶液的外观、pH值以及两种药物的含量变化。结果:丙泊酚中/长链脂肪乳注射液中加入盐酸利多卡因注射液,6 h内利多卡因与丙泊酚含量变化均<3%,外观、pH值均无显著变化。结论:丙泊酚与小剂量的利多卡因配伍后6h内含量、外观、pH值稳定。
OBJECTIVE： To investigate the compatiblity stability of Propofol medium and long chain fat emulsion injection mixed with small dose of Lidocaine hydrochloride injection. METHODS： Lidocaine hydrochloride injection 0.25, 0.5 and 1 ml （containing lidocaine hydrochloride 5, 10 and 20 mg） were added into 20 ml Propofol medium and long chain fat emulsion injec- tion. The appearance, pH value and content variation of mixture were investigated within 6 h. RESULTS ： The content changes of li- docaine and propofol were less than 3 % within 6 hours after the compatibility solution prepared. No significant change in appear- ance and pH value was observed. CONCLUSIONS： The appearance, pH and content of compatibility solution are stable within 6 h after the propofol mixed with small dose of lidocaine.
出处
《中国药房》
CAS
CSCD
2014年第38期3603-3605,共3页
China Pharmacy
