摘要
目的：探讨腹膜透析患者出现神经精神症状的原因、临床表现和转归。方法选取2011年6月～2013年5月我院收治的出现神经精神症状的腹膜透析患者40例作为观察组，选取同期无神经精神症状的腹膜透析患者24例作为对照组，分析出现神经精神症状的原因，比较两组年龄、透析龄、血压和肾功能指标。结果腹膜透析患者出现神经精神症状的常见原因包括毒物蓄积、代谢紊乱、透析失衡、脑血管意外、营养物质缺乏、药物蓄积等；观察组在年龄、透析龄、血压和肾功能指标上与对照组比较无统计学差异（P＞0.05）；35例患者症状缓解，1例患者死亡，死亡率为2.5%。结论造成腹膜透析患者出现神经精神症状的原因比较复杂，主要是毒物蓄积、代谢紊乱、透析失衡、脑血管意外，要积极加强对患者原发病的治疗，随时调整药量和抗生素剂量，促进患者的转归。
Objective To explore the causes, clinical manifestation and outcome of neuropsychiatric symptoms in patients with peritoneal dialysis. Methods During June 2011 to May 2013, 40 cases of peritoneal dialysis patients with neuropsychiatric symptoms were selected as the observation group, 24 cases of peritoneal dialysis patients without neuropsychiatric symptoms were selected as the control group. Analysis of the causes of neuropsychiatric symptoms, compared with two groups of age, dialysis ages, blood pressure and renal function index. Results The common causes of neuropsychiatric symptoms in patients with peritoneal dialysis included poison accumulation, metabolic disorder, dialysis disequilibrium, cerebrovascular accident, nutrient deficiency, drug accumulation etc. The age, dialysis ages, blood pressure level and serum creatinine level of observation group had no difference with the control group （P 〉0.05）; 35 patients with symptoms relief, and 1 patient died, the mortality rate was 2.5%. Conclusion The causes of neuropsychiatric symptoms in patients with peritoneal dialysis was complex, mainly including poison accumulation, metabolic disorder, dialysis disequilibrium, cerebrovascular accident, we should actively strengthen the treatment of patients＇s primary disease, feel free to adjust the doses of drug and antibiotics, and promote the patient＇s outcome.
出处
《中国医药科学》
2014年第20期185-187,共3页
China Medicine And Pharmacy
关键词
腹膜透析
神经精神症状
原因
转归
Peritoneal dialysis
Neuropsychiatric symptoms
Causes
Outcome
