摘要
目的 探讨影响维持性血液透析（MHD）患者神经精神并发症的临床因素，提高临床诊治水平。方法 经神经、精神专科医生确诊，将101例慢性肾衰竭MHD患者分为神经精神症状阳性组（阳性组）和神经精神症状阴性组（阴性组），回顾性分析其临床资料，对比两组的一般资料、生化指标和透析剂量，作统计学分析。结果 阳性组中老年和高龄患者居多，平均年龄57．2岁，高于阴性组；阳性组单次透析剂量（Kt／V）低于阴性组但无统计学意义（P〉0．05）；部分电解质（Na^＋、Cl^-）指标明显低于阴性组（P〈0．05）。结论 慢性肾衰竭MHD患者的神经精神症状与年龄、透析不充分、电解质紊乱、药物副作用等多种因素有关；应尽早明确颅内病变性质，对有神经精神症状者透析处方应个体化，及时纠正代谢紊乱，同时积极治疗原发病。
Objective To investigate the clinical risk factors for central nervous dysfunction in chronic renal failure patients on MHD and promote the level of diagnosis. Methods 101 cases of chronic renal failure patients on MIlD were dichotomized on the basis of the presence of central neurological and psychiatric symptoms into positive and negative group. Clinical indices such as age, biochemical data ,hemodialysis dose were analysed retrospectively. Results Most of the positive patients were old, the average age of the positive group was older than that of the negative group. Dialysis dose （Kt/ V） in the positive ones was lower than that of the controls but with no statistical significance （P〉 0. 05）. A part of electrolyte indexes （ Na^＋ ,Cl^- ） in the positive group were significantly lower than in the negative one（P〈0. 05）. Conclusions Central nervous dysfunction in MHD patients results from multiple factors. Cerebrovascular accident should be excluded on the early stage. Prescription of hemodialysis for positive patients should be individualized and electrolytes disturbances be corrected in time.
出处
《临床肾脏病杂志》
2005年第4期161-163,共3页
Journal Of Clinical Nephrology
