摘要
目的探讨苯丙酮尿症(PKU)患儿早发现、早治疗及治疗依从性对患儿智能发育的影响。方法选取邢台市2002-2012年经新生儿筛查确诊的苯丙酮尿症患儿41例,门诊就诊PKU患儿3例,选用Gesell发育量评估患儿智能发育情况。结果通过新生儿疾病筛查、确诊并早期治疗的37例PKU患儿多数智能发育达到正常水平,但平均发育年龄与实际年龄相比,适应性、语言能区均较落后,差异有统计学意义(P<0.05),其他3个能区,差异无统计学意义。虽早期发现但未及时治疗的4例和门诊就诊的3例PKU患儿因治疗较晚,智力发育水平均较差,与早期治疗患儿比较智能发育各个能区均较落后,差异有统计学意义(P<0.05)。37例早期治疗的PKU患儿中不配合组智能发育各个能区均落后于完全配合治疗组,差异有统计学意义(P<0.05)。结论临床上,PKU患儿病情影响因素较多,医护人员要根据患儿实际情况采取有效方法治疗,治疗时家长的配合能够有效地降低患儿智能水平发生率。
Objective To explore the effect of early detection, early treatment and treatment compliance on the intellectual development of children with phenylketonuria（PKU）. Methods Forty-one children with PKU were selected in Xingtai from 2002 to 2012 by neonatal screening, and 3 were enrolled from Outpatient Department. Gesell developmental Schedule was applied to assess the intellectual development of the children. Results Through neonatal screening, early diagnosis and treatment, 37 children＇s most intellectual development reached normal levels, but developmental age was lag behind the actual age, with significantly lagged adaptability and language function（P〈0.05）.The other three function areas showed no statistically significant difference. The 4 children with early diagnosis but not timely treatment and the 3 children from Outpatient Department were found to have poor intellectual developmental level due to late treatment, compared with children with early treatment, showing statistically significant difference with the children of early treatment（P〈0.05）. Among the 37 children of early treatment, the children fully cooperating with treatment had significantly better intellectual developmental level than those not fully cooperating with treatment（P〈0.05）. Conclusion Clinically, PKU children have lots of influence factors. Medical personnel should take effective treatment according to the actual situation, and parents＇ cooperation can effectively reduce the incidence of low intelligence level.
出处
《海南医学》
CAS
2014年第19期2840-2842,共3页
Hainan Medical Journal
基金
邢台市科学技术研究与发展计划课题(编号:2012ZZ031-12)
关键词
苯丙酮尿症
依从性
新生儿筛查
智能发育
Phenylketonuria
Compliance
Neonatal screening
Intellectual development
