摘要
目的了解妊娠期糖尿病(gestafional diabetes mellitus,GDM)患者应用盐酸利托君保胎的疗效及安全性。方法选取2011年3月—2013年3月在上海市第一人民医院宝山分院妇产科妊娠期糖尿病合并先兆早产的47名患者作为研究对象,研究组是26名GDM患者应用盐酸利托君保胎,21名应用硫酸镁保胎的GDM患者作为对照组。计量资料数据以(x±s)表示,采用SPSS 13.0软件进行统计分析,组间比较采用t检验,P<0.05为差异有统计学意义;2组患者在年龄、孕周、孕次、有无糖尿病家族史、用药前空腹及餐后2 h血糖控制情况差异均无统计学意义(P>0.05);比较2组间的妊娠延长时间、空腹及餐后2 h血糖的变化情况。结果 2组患者妊娠延长时间情况差异有统计学意义(P<0.05)。研究组应用盐酸利托君后空腹血糖及餐后2 h有所升高,但波动幅度小,用药后的空腹血糖及餐后2 h血糖变化差异无统计学意义(P>0.05),停药后3 d血糖降至用药前水平。结论盐酸利托君应用于妊娠期糖尿病孕妇保胎治疗中是相对安全的、有效的,其效果优于硫酸镁。
Objective To observe the efficacy and safety of ritodrine hydrochloride in the treatment of the threatened pre- mature labor in pregnant women with gestational diabetes mellitus （GDM）. Methods Total 47 pregnant women with ges- tational diabetes mellitus and a diagnosis of threatened premature labor from March 2011 to March 2013 in our hospital were enrolled and randomly divided into two groups. 26 cases in the experimental group received ritodrine hydrochloride to protect the fetus, and 21 cases in the control group were administered with magnesium sulfate. The prolonged time of preg- nancy,fasting blood-glucose and 2-hour postprandial blood glucose were compared between groups by t-test with SPSS 13.0. Results There was no statistical difference in the age, gestational age, times of pregnancy, family history of diabetes mellitus, fasting blood-glucose and 2-hour postprandial blood glucose before medication（ P 〉 0.05 ）. The difference in the prolonged time of pregnancy was statistically significant （ P 〈 0.05 ）. The levels of fasting blood-glucose and 2-hour postprandial blood glucose had small fluctuations after the ritodrine hydrochloride administration, but the difference was not significant （ P 〉 0. 05 ）. The blood-glucose levels recovered 3 days after the withdrawal. Conclusion Ritodrine hydro- chloride for the threatened premature labor in pregnant women with gestational diabetes mellitus is safe and effective, and better than magnesium sulfate.
出处
《中华全科医学》
2014年第12期1973-1974,共2页
Chinese Journal of General Practice
关键词
盐酸利托君
妊娠期糖尿病
早产
Ritodrine hydrochloride
Gestational diabetes mellitus
Prematurity
