摘要
小儿支气管哮喘(哮喘)的病理生理机制尚未完全清楚。气道重塑是其中重要的病理生理改变,参与了哮喘的发生、发展过程。解整合素-金属蛋白酶33(ADAM33)基因为哮喘的易感性基因,研究表明其与气道重塑密切相关。该文就ADAM33在哮喘气道重塑中的作用机制进行阐述,以阐明哮喘发生的基因机制。
The pathophysiological mechanism of pediatric asthma remains elusive.Airway remodeling is part of the main pathophysiological changes which are involved in the incidence and development of asthma.A disintegrin and metalloprotease 33 （ADAM33）has been proven to be a susceptibility gene of asthma,which is closely associated with airway remodeling.This article reviewed the underlying mechanism of ADAM33 in airway remodeling in patients with asthma,and to elucidate the genetic mechanism of asthma.
出处
《新医学》
2014年第10期635-639,共5页
Journal of New Medicine
