摘要
目的 观察重组人粒细胞巨噬细胞集落刺激因子（rhGM-CSF）早期干预对鼻咽癌患者放射性口腔黏膜炎的疗效.方法 将75例鼻咽癌患者按随机数字表法分为预防组、治疗组、对照组各25例,预防组为放疗第一天开始使用rhGM-CSF漱口,治疗组和对照组为放疗至出现口腔黏膜炎开始分别使用rhGM-CSF漱口及对照药物（0.9％氯化钠溶液500 ml＋维生素B1240 mg＋丁卡因100 mg）漱口.采用通用毒性标准（CTC）评价和记录口腔黏膜炎发生时间及损伤程度.结果 预防组口腔黏膜炎发生时间较治疗组和对照组延迟,差异具有统计学意义[预防组、治疗组及对照组分别为（15.2±3.2）、（12.1±2.7）、（12.0±2.6）d;t=3.725,P=0.001;t=3.939,P=0.000],口腔黏膜损伤程度方面,预防组较对照组、治疗组减轻,预防组Ⅱ级及以上口腔黏膜炎发生率为68％（17/25）,治疗组为92％（23/25）,对照组为100％（25/25）（P=0.000）.亚组分析结果显示,预防用药能更好降低Ⅱ级及以上口腔黏膜炎发生率（P＜0.05）,治疗用药能更好地降低Ⅱ级及以上口腔黏膜炎发生率（P＜0.05）.结论 rhGM-CSF早期干预能更好地改善鼻咽癌患者放射性口腔黏膜炎.
Objective To evaluate the early intervention efforts of recombinant human granulocyte macrophage colony-stimulating factor （rhGM-CSF） against nasopharyngeal cancer with radiation-induced oral mucositis.Methods A total of 75 patients with nasopharyngeal cancer were randomly assigned to 3 groups：the prevention group （n =25） used rhGM-CSF when radiation started one day,the treatment group （n =25） and the control group （n =25） used rhGM-CSF when oral mucositis occurred.Criteria of CTC was used to evaluate the duration of oral mucositis and degree of oral pain.Results The prevention group had a longer duration of oral mucositis of oral mucositis when comparing with the treatment group and the control group （15.2±3.2）,（12.1±2.7）,（12.0±2.6） d （t =3.725,P =0.001; t =3.939,P =0.000）.As compared with the control and experiment group,the degree of mucosal damage in the prevention group was significantly lower.Ⅱ level and above oral mucositis were about 68 ％ （17/25）,92 ％ （23/25） and 100 ％ （25/25） respectively （P =0.000）.According to subgroup analysis,prophylactic rhGM-CSF in radiation-induced oral mucositis can better reduce the incidence of Ⅱ level and above oral mucositis （P ＜ 0.05）,and treatment group can reduce the incidence of Ⅲ level oral mucositis （P ＜ 0.05）.Conclusion rhGM-CSF early intervention can better improve nasopharyngeal cancer with radiation-induced oral mucositis.
出处
《肿瘤研究与临床》
CAS
2014年第9期626-628,共3页
Cancer Research and Clinic
关键词
粒细胞巨噬细胞集落刺激因子
重组
鼻咽肿瘤
放射性口腔黏膜炎
Granulocyte macrophage colony-stimulating factors, recombinant
Nasopharyngeal neoplasms
Radiation oral mucositis
