摘要
目的:研究中医辨证方法治疗老年性痴呆患者的疗效。方法:选择2011年1月—2013年10月本科接诊的60例老年性痴呆的患者进行研究。按照随机数表法,随机均分为观察组和对照组。对照组采用常规西药治疗,观察组采用中医辨证分型进行治疗。治疗后,分析比较两组患者的血脂及血液流变学的变化情况,采用简易智力状态量表(MMSE)、日常能力量表积分(ADL)及蒙特利尔认知量表(MoCA)对两组患者的认知、行为功能进行评分,并采用相关疗效评价标准评价两组患者的疗效及不良反应情况。结果:治疗后,观察组患者的血脂及血液流变学各指标均明显改善,治疗前后比较有显著性差异(P<0.01);对照组患者治疗前后的血脂及血液流变学各指标无显著改变(P>0.05)。两组患者的MMSE及MoCA评分均明显升高(P<0.01),ADL均明显降低(P<0.01),但观察组患者治疗后的MMSE及MoCA均明显高于对照组(P<0.01),ADL评分明显低于对照组(P<0.01)。观察组患者的总有效率(86.67%)明显高于对照组(53.33%),两组有效率比较有统计学意义(u=-2.0180,P=0.0436)。两组患者的不良反应发生率无显著性差异(χ2=0.7407,P=0.3894)。结论:中医辨证方法治疗老年性痴呆患者的疗效显著,值得临床推广。
Objective ： To study the curative effect of syndrome differentiation of traditional Chinese medicine treatment for Alzheimer＇s disease. Methods ：60 cases with Alzheimer＇s disease patients from January 2011 to October 2013 in our hospital were studied. According to a random number table method, they were randomly divided into observation group and control group. The control group was treated with conventional treatment measures while the observation group treated with syndrome differentiation of traditional Chinese medicine. After treatment, changes in lipid and hemorheology of the two groups were compared. The mini - mental state examination （MMSE） ,the daily capacity scale integration （ADL） and the Montreal Cognitive Scale （MoCA） of the two groups were used to evaluate the behavioral function score and the use of efficacy and adverse reactions related to efficacy evaluation criteria was evaluated. Results ： After treatment, the blood rheology parameters of the observation group were significantly improved and there was a significant difference （ P 〈 0.01 ）. The blood rheology of the control group before and after treatment did not change significantly （P 〉 0.05 ）. The MMSE and MoCA scores were significantly higher （P 〈 0.01 ） and ADL was signifi- cantly lower （P 〈0.01 ） but the MMSE and MoCA were significantly higher （P 〈0.01 ） in two groups. ADL scores in the obser- vation group were significantly lower than that of the control group （P 〈 0.01 ）. The total efficiency of observation group （86. 67% ） was significantly higher than that of the control group （53.33%） and the efficiency of the two groups was statistically sig- nificant （u = -2. 0180, P = 0. 0436）. The incidence of adverse reactions of the two groups were not significantly different （x^2 = 0. 7407, P = 0.3894）. Conclusion ： Chinese syndrome differentiation therapy treatment for Alzheimer＇s patients is remarkable, worthy of promotion.
出处
《辽宁中医杂志》
CAS
2014年第10期2164-2166,共3页
Liaoning Journal of Traditional Chinese Medicine
关键词
痴呆
老年性
中医
辨证
dementia
elderly
traditional Chinese medicine
sydnrome differentiation
