摘要
为研究中药四妙君逸软膏的镇痛作用及其相关机理，应用醋酸致痛小鼠实验和蟾蜍局麻实验研究四妙君逸软膏的镇痛作用，并测定小鼠血清中PGE2的含量和脑组织中5-HT2A受体的数量。结果显示，四妙君逸软膏能明显抑制醋酸致痛模型小鼠的扭体反应，使脊蟾蜍的。缩腿反射消失，降低小鼠血清中PGE。的含量及增加脑组织中5-HT2A受体表达的数量。结果表明，四妙君逸软膏对中枢和外周神经均具有镇痛作用，其镇痛机理可能与减少血清PGE2含量、增加脑组织5-HT2A受体表达有关。
This study was to investigate the analgesic effects and mechanism of Simiao Junyi ointment（a Chinese medicine formula）.The experimental study on acetic acid induced pain in rats and local anesthesia of toads was conducted.The serum level of PGE2 in mice and the number of 5-HT2A receptors in their brain tissues were determined.The results showed that Simiao Junyi ointment could significantly inhibit writhing response in mice model of acetic acid-induced pain, made pithed toads leg flinching reflex disappeared, re- duced the serum level of PGE2 in mice and increased the number of 5-HT2A receptor expression in brain tis- sues.It is concluded that Simiao Junyi ointment has both central and peripheral nerve analgesic effects, which may be related to the reduced level of serum PGE2 and increased expression of 5-HT2A receptor in the brain tissue.
出处
《中国肛肠病杂志》
2014年第9期7-9,共3页
Chinese Journal of Coloproctology
基金
国家自然科学基金资助项目（编号：81173262）
关键词
四妙君逸软膏
镇痛
实验研究
Simiao J unyi Ointment
Analgesia
Experimental study
