摘要
目的探讨肢端肥大症型垂体腺瘤MRI特点及其与血清生长激素（GH）水平、肿瘤GH表达水平之间的关系。方法回顾性分析2008年1月~2013年6月采用经鼻蝶入路显微手术切除的84例肢端肥大症型垂体腺瘤患者的临床资料。结果 MRI显示肿瘤可突破鞍膈向鞍上生长、突破鞍底向蝶窦内生长,鞍下侵犯指数[（2.35±0.69）cm]明显高于鞍上侵犯指数[（0.66±0.25）cm;P〈0.01]。术前血清GH水平与瘤体大小、肿瘤GH表达水平之间无明显相关性（P〉0.05）。结论肢端肥大症型垂体腺瘤有明显的向蝶窦内优先侵犯生长的趋势;其术前血清GH水平、肿瘤GH表达水平及瘤体大小之间无明显相关性。
Objective To explore the MRI characteristics of the pituitary adenomas and relationships among the adenomas volume, basic serum growth hormone（GH） level, pathological immune responses in the patients with acromegaly.Methods The clinical data of 84 acromegaly patients with pituitary adenomas, who underwent microsurgery via single-nostril transspheniodal approach from January, 2008 to June, 2013, were analyzed retrospectively.Results MRI showed that some tumors broke the sellar diaphragm into suprasellar regions or the sellar floor into the sphenoid sinuses. Infrasellar invasion index [（2.35±0.69） cm] was significantly higher than that [（0.66±0.25） cm] of suprasellar invasion index（P〈0.01）. There was no significant correlation among the preoperative basic serum GH level, tumor volume and GH immune response strength（optical density value）（P〉0.05）.Conclusions The pituitary adenomas volumes are insignificantly related to the preoperative basic serum GH level, and GH pathological immune response strength in the patients with cromegaly, in whom the pituitary adenomas trends to growth into the sphenoid sinuses.
出处
《中国临床神经外科杂志》
2014年第9期516-518,共3页
Chinese Journal of Clinical Neurosurgery
关键词
垂体腺瘤
肢端肥大症
MRI特点
生长激素
Acromegaly
Pituitary adenoma
Growth hormone
Immune response
MRI characteristics
