摘要
目的探讨肢端肥大症患者病情活动期与缓解后身体组分的变化与生长激素(GH)、类胰岛素生长因子-1(IGF-1)水平的相关性。方法治疗前后患者做生长激素葡萄糖抑制试验(OGTT),测定GH谷值、空腹IGF-1水平;使用体脂分析仪测定身高、体质量、脂肪百分含量(fat%)、去脂肪量(FFM)和身体总水量(TBW)。结果活动期男性患者体重指数(BMI)和FFM显著高于正常对照,脂肪百分含量则显著低于后者;缓解后,患者GH谷值和IGF-1水平明显下降,BMI仍显著高于正常男性,而脂肪百分含量和FFM分别呈现增加和减少的趋势,与GH谷值和IGF1水平的降低显著相关。活动期女性患者与正常女性比较,BMI、FFM显著高于后者,而两者脂肪百分含量无显著差异;缓解后,患者FFM逐渐减少,与GH谷值显著相关,脂肪百分含量无明显变化。结论肢端肥大症患者身体组分与正常人相比差异显著。缓解后身体组分发生变化,与GH谷值、IGF-1水平密切相关。
Objective To identify the changes of body composition with acromegaly before and after pituitary adenoma surgery,and to evaluate the relationship between these changes and serum growth hormone（GH）,insulin-like growth factor-1（IGF-1）.Methods Serum GH with OGTT,IGF-1 levels,BMI,fat percentage,FFM and total body water（TBW） in patients were measured in active and relieved period of the disease.Results The BMI and FFM with active acromegalic males were significantly higher,but fat percentage was significantly lower than that of healthy males.After the disease was relieved by surgery,serum GH and IGF-1 concentrations of patients were significantly reduced to normal level,but their BMI was still significantly higher,the fat percentage increased and the FFM decreased was correlated with serum nadin GH and IGF-1 levels.The BMI and FFM with active acromegalic females were significantly higher than healthy females,but the fat percentage had not significant change after surgery,and FFM decrease was correlated with reduced serum GH level.The fat percentage did not change significantly.Conclusion There was significant change of body composition with acromagely before and after treatment,and a relationship between these changes and serum GH and IGF-1 levels was identified.
出处
《基础医学与临床》
CSCD
北大核心
2010年第4期411-414,共4页
Basic and Clinical Medicine
