摘要
目的：调查留置尿管相关性尿路感染的病原菌分布及其耐药性，为临床合理预防治疗留置尿管相关性尿路感染提供依据。方法回顾性分析医院2011年1月-2014年5月134例留置尿管相关性尿路感染患者的临床资料，调查感染病原菌的种类及其耐药性，细菌鉴定采用法国生物梅里埃公司全自动细菌鉴定系统及其配套试剂进行，药敏试验采用纸片扩散法，数据采用SPSS 13．0软件进行统计处理。结果3428例留置尿管患者中134例发生相关性尿路感染，感染率为3．9％；共分离出病原菌200株，其中革兰阴性菌132株占66．0％，革兰阳性菌48株占24．0％，真菌20株占10．0％；革兰阴性菌对亚胺培南和美罗培南的耐药率均为0，革兰阳性菌对替考拉宁的耐药率为0～3．7％，对呋喃妥因耐药率为3．7％～16．7％，对万古霉素和利奈唑胺的耐药率为0。结论加强临床感染病原菌分布及其耐药性检测，有利于提高临床治疗效果，指导临床合理使用抗菌药物。
OBJECTIVE To investigate the distribution and drug resistance of pathogens in catheter-related urinary tract infection ,and to provide evidence for clinical rational control of catheter associated urinary tract infection . METHODS A retrospective analysis was conducted on the clinical data of 134 patients with catheter-related urinary tract infection who were treated in our hospital from Jan .2011-May 2014 ,and the variety and drug resistance of pathogens was investigated . The full-automatic bacterial identification system （Biomerieux , France） and its supplementary reagent were used for bacterial identification and the disk diffusion method was used for drug sensitivity test .Data were statistically processed by the software SPSS 13 .0 .RESULTS Totally 134 in 3 428 patients with urinary catheter had catheter-related urinary tract infection ,indicating the infection rate was 3 .9% . There were 200 strains identified ,including 132 strains of gram-negative bacteria （66% ） ,48 strains of gram-positive bacteria （24 .0% ） ,and 20 strains of fungi （10 .0% ） .The gram-negative bacteria had 0% resistance to imipenem and meropenem ,and gram-positive bacteria showed 0 -3 .7% resistance to teicoplanin and 3 .7%-16 .7% to nitrofurantoin , and 0% to vancomycin and linezolid . CONCLUSION Strengthening the test of distribution and drug resistance of pathogens is conductive to improve clinical effect and guide the clinical rational use of antimicrobial agents .
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2014年第20期5019-5021,共3页
Chinese Journal of Nosocomiology
基金
重庆市卫生局基金资助项目(2013-2-169)
关键词
留置尿管
尿路感染
病原菌
耐药性
Indwelling catheter
Urinary tract infection
Pathogen
Drug resistance
