摘要
目的 观察经皮电神经刺激（TENS）肺俞穴对慢性阻塞性肺疾病（COPD）患者肺功能及诱导痰中肿瘤坏死因子-α（TNF-α）浓度的影响.方法 采用随机数字表法将30例轻、中度（肺功能Ⅰ-Ⅱ级）COPD患者分为治疗组及对照组,每组15例.治疗组患者给予肺俞穴经皮电神经刺激治疗,对照组患者则给予肺俞穴经皮神经假刺激治疗.于治疗前、治疗4周后分别对2组患者肺功能,体质指数-气流阻塞-呼吸困难-运动能力（BODE）指数及诱导痰中TNF-α浓度进行检测.结果 治疗前2组患者肺功能[包括用力肺活量（FVC）、1秒用力呼气容积（FEV1）、1秒用力呼气容积与用力肺活量比值（FEV1％）及呼气峰值流速（PEFR）]、BODE指数及诱导痰中TNF-α浓度组间差异均无统计学意义（P＞0.05）;分别经4周治疗后,发现治疗组FVC[（2.75 ±0.77）L]、FEV1 [（1.77±0.50）L]、FEV1％ [（73.20±7.69）％]及PEFR[（4.33±1.09） L/S]均较治疗前及对照组明显改善（P＜0.05）;治疗组治疗后诱导痰中TNF-α浓度[（14.27±2.78） pg/ml]、BODE指数[（0.43±0.65）分]亦较治疗前及对照组明显下降（P＜0.05）,而对照组上述指标治疗前、后均无明显变化（P＞0.05）.结论 肺俞穴经皮电神经刺激能缓解轻、中度COPD患者气道炎性反应,改善肺功能,降低其BODE指数,对提高患者日常生活活动能力具有重要意义.
Objective To observe any effect of transcutaneous electrical nerve stimulation （TENS） on pul monary function,airflow obstruction,dyspnea,exercise capacity and levels of tumor necrosis factor-α （TNF-α） in the sputum of patients with chronic obstructive pulmonary disease （COPD）.Methods Thirty patients with stage Ⅰ or Ⅱ COPD were randomly divided into a treatment group and a control group with 15 cases in each.TENS applied at the Feishu acupuncture point （BL13） was used in the treatment group,while sham stimulation of the same point without current output was used in the control group.The treatment was administered 40 minutes once daily,5 days a week for a total of 4 weeks.The outcome measures were measured before and after 4 weeks of treatment.Results FVC,FEV1,FEV1%,and peak expiratory flow rate （PEFR） all improved significantly in the treatment group after 4 weeks of treatment.After treatment,the average TNF-α level in induced sputum and exercise capacity as indicated by the average BODE index had both improved significantly in the treatment group.Compared with the control group,pulmonary function,TNF-α and the BODE index in the treatment group were all significantly better.There was no significant difference in pulmonary function,BODE index or TNF-α before and after treatment in the control group.Conclusion TENS at the Feishu acupoint can reduce airway inflammation,improve pulmonary function and exercise capacity,and decrease TNF-α levels in patients with stage Ⅰ or Ⅱ COPD.This treatment should be very useful for enhancing their ability in the activities of daily living.
出处
《中华物理医学与康复杂志》
CAS
CSCD
北大核心
2014年第9期705-708,共4页
Chinese Journal of Physical Medicine and Rehabilitation
基金
浙江省医药卫生一般研究计划2011KYB041
关键词
慢性阻塞性肺疾病
经皮电神经刺激
肺俞穴
肺功能
BODE指数
肿瘤坏死因子-Α
Chronic obstructive pulmonary disease
Lungs
Transcutaneous electrical nerve stimulation
Acupuncture
Pulmonary function
Exercise capacity
Tumor necrosis factor α
