摘要
目的检测中枢神经系统(CNS)脱髓鞘疾病患者血清水通道蛋白4抗体(即NMO-IgG)的表达,并探讨其对视神经脊髓炎(neuromyelitis optica,NMO)的诊断价值。方法收集2011-01-2013-01就诊于中国医科大学附属第一医院神经内科的CNS脱髓鞘疾病患者50例〔其中NMO患者10例,长节段横惯性脊髓炎(longitudinally extensive transverse myelitis,LETM)患者10例,多发性硬化(multiple sclerosis,MS)患者30例〕及30名健康人的血清,采用ELISA试剂盒检测血清NMO-IgG水平。结果 NMO组、LETM组、MS组及健康对照组NMO-IgG的阳性率分别为60%(6/10)、50%(5/10)、10%(3/30)、0(0/30)。NMO组与LETM组NMO-IgG阳性率均高于MS组(P<0.05)。NMO-IgG诊断NMO的灵敏度为60%,特异度为95%(57/60)。结论 NMO和LETM患者血清NMO-IgG阳性率均较高,支持两者同属于视神经脊髓炎疾病谱(neuromyelitis optica spectrum disorders,NMOSD);NMO的诊断标准仍需建立在临床及MRI诊断的基础之上,NMO-IgG可作为一项重要的辅助诊断指标,有助于NMO的鉴别诊断。
Objective To detect the expression of serum aquaporin-4 antibodies （NMO-IgG） in patients with central nervous system （CNS） demyelinative diseases and to analyze its diagnostic value to neuromyelitis optica （NMO）.Methods The study included 10 NMO patients,10 longitudinally extensive transverse myelitis （LETM） patients,30 multiple sclerosis （MS） patients and 30 healthy people as control.The level of serum NMO-IgG was detected by ELISA.Results The positive ratios of serum NMO-IgG were 60％ （6/10） in NMO patients,50％ （5/10） in LETM patients,10％ （3/30） in MS patients and 0 （0/30） in healthy people.The positive ratios in NMO and LETM were higher than that in MS （P＜0.05）.The sensitivity of NMO-IgG was 60％ for NMO diagnosis,and its specificity reached 95％.Conclusions The positive ratios of serum NMO-IgG were higher in NMO and LETM patients,which supports the opinion that they both belong to neuromyelitis optica spectrum disorders （NMOSD）,the diagnosis of NMO should be based on clinical characteristics and MRI manifestation rather than NMO-IgG,but it can help to differentiate NMO from other CNS diseases.
出处
《中国神经免疫学和神经病学杂志》
CAS
北大核心
2014年第5期332-334,共3页
Chinese Journal of Neuroimmunology and Neurology
