期刊文献+

环维黄杨星D对高交感活性诱导大鼠实验性心肌损伤氧化应激及能量代谢的影响 被引量:7

Ameliorated Effects of Cyclovirobuxine D on Oxidative Stress and Energy Metabolism in Experimental Cardiac Injured Rats Induced by Sympathetic Overactivity in vivo
下载PDF
导出
摘要 目的:研究环维黄杨星D对高交感活性诱导大鼠实验性心肌损伤氧化应激及能量代谢障碍的改善作用。方法:SD大鼠随机分为正常对照组、模型组、维生素E组及环维黄杨星D低、高剂量组,除正常对照组外其余各组均腹腔注射去甲肾上腺素(Noradrenaline,NE)复制实验性心肌损伤模型,同时灌胃给予相应药物,连续给药16d,期间检测各组动物体质量变化,16 d后进行心指数、羟脯氨酸含量、组织病理学检查、氧化/抗氧化指标(MDA、SOD、CAT、GSH-Px、T-AOC)、能量代谢指标(Na+,K+-ATPase、Ca2+,Mg2+-ATPase)的测定。结果:环维黄杨星D低、高剂量组均不同程度增加动物体质量,降低心指数及羟脯氨酸含量,改善氧化/抗氧化失衡,改善能量代谢障碍。结论:环维黄杨星D对高交感活性诱导的实验性心肌损伤氧化应激及能量代谢障碍具有显著的保护作用。 Objective: To investigate the ameliorated effect of CVB-D on oxidative stress and energy metabolism in experimental cardiac injuried rats induced by sympathetic overactivity in vivo.Methods: SD rats were randomly divided into five groups as following:control group,model group,Vitamin E 150 mg /kg group,CVB-D low dose and high dose groups,respectively.The rat experimental cardiac injury model was established by exposed to norepinephrine( NE) 3 mg /kg by ip for 16 d.The drugs were administrated to rat for 16 d by ig.The body weight of rats were monitored during all of the experimental period.At the designing ending-time point the indexes were assayed as following: cardiac index,hydroxyproline,histopathologically examination,oxidative stress( MDA,SOD,CAT,GSH-Px and T-AOC) and energy metabolism indicatricle( Na+,K+-ATPase,and Ca2 +,Mg2 +-ATPase).Results: After exposed with NE for 16 d,the rats of model group was appeared dysfunction of oxidative stress and energy metabolism such as decreasing body weight,increasing cardiac index and hydroxyproline in cardiac tissue,decreasing Na+,K+-ATPase and Ca2 +,Mg2 +-ATPase activities,and deteriorating the oxidative stress.Treated with CVB-D could ameliorate all of the exacerbated indexes.Conclusion: CVB-D has protective effect against oxidative stress and energy metabolism in rats of experimental myocardial injury induced by sympathetic overactivity.
出处 《中药材》 CAS CSCD 北大核心 2014年第7期1213-1217,共5页 Journal of Chinese Medicinal Materials
基金 国家自然科学基金(81173586) 教育部新世纪优秀人才支持计划(NCET-13-0747) 贵州省省长专项资金项目(黔科教办[2011]28号) 贵州省社会发展攻关项目(黔科合SY字[2011]3011号 [2012]3085号)
关键词 高交感活性 氧化应激 能量代谢 心肌损伤 环维黄杨星D Sympathetic overactivity Oxidative stress Energy metabolism Cardiac injury CVB-D
  • 相关文献

参考文献10

  • 1Lyngkaran P,Anavekar N,Majoni W,et al.The role and management of sympathetic overactivity in cardiovascular and renal complications of diabetes[J].Diabetes Metab,2013,39(4):290-298. 被引量:1
  • 2张彦燕,柏帅,沈祥春.高交感活性诱导心肌损伤氧化应激受体依赖机制研究[J].中药药理与临床,2012,28(3):120-121. 被引量:1
  • 3Yu B,Fang TH,Lu GH,et al.Benefical effect of cyclovirobuxine D on heart failure rats following myocardial infarction[J].Fitoterapia,2011,82(6):868-877. 被引量:1
  • 4Shen XC,Qian ZY.Effects of crocetin on antioxidant enzymatic activities in cardiac hypertrophy induced by norepinephrine in rats[J].Pharmazie,2006,61(4):348-352. 被引量:1
  • 5Shen XC,Qian ZY,Wang YJ,et al.Crocetin attenuates norepinephrine-induced cytotoxicity in primary cultured rat cardiac myocytes by antioxidant in vitro[J].J Asian Nat Prod Res,2009,11(5):417-425. 被引量:1
  • 6Neri M,Cerretani D,Fiaschi AI,et al.Correlation between cardiac oxidative stress and myocardial pathology due to acute and chronic norepinephrine administration in rats[J].J Cell Mol Med,2007,11(1):156-170. 被引量:1
  • 7常文静,赵智明,董晓蕾,赵凌杰,蔡辉.丹参酮ⅡA对压力负荷增加大鼠心肌促纤维化细胞因子表达的影响[J].中国心血管杂志,2013,18(4):286-290. 被引量:4
  • 8曹忠平.活性氧与细胞信号转导[J].武警医学院学报,2011,20(8):666-668. 被引量:7
  • 9Shen XC,Tao L,Li WK,et al.Evidence-based antioxidant activity of the essential oil from Fructus A.zerumbet on cultured human umbilical vein endothelial bells'injury induced by ox-LDL[J].BMC Complementary and Alternative Medicine,2012,12:174. 被引量:1
  • 10Bombardier E,Smith IC,Vigna C,et al.Ablation of sarcolipin decreases the energy requirements for Ca2+transport by sarco(endo)plasmic reticulum Ca2+-ATPases in resting skeletal muscle[J].FEBS Lett,2013,587(11):1687-1692. 被引量:1

二级参考文献35

  • 1Touyz RM. Reactive oxygen species as mediators of calcium signaling by angiotensin II: implications in vascular physiology and pathophysiology[J]. Antioxid Redox Signaling, 2005, 7(9-10):1302-1314. 被引量:1
  • 2Giuseppe B, Serafina P, Maria LT. Oxygen toxicity: chemistry and biology of reactive oxygen species[J]. Semi in Fetal and Neonatal Med, 2010, 15(4):186-190. 被引量:1
  • 3Chevtzoff C, Yoboue ED, Galinier A, et al. Reactive oxygen species-mediated regulation of mitochondrial biogenesis in the yeast Saccharomyces cerevisiae[J]. J Biol Chem, 2010, 285(3): 1733-1742. 被引量:1
  • 4Sonia C, Renato X, Maria S, et al. Mitochondrial reactive oxygen species preconditioning protects brain cells against hyperglycemia[J]. Alzhe & Dem, 2010, 6(4):557-566. 被引量:1
  • 5Gyorgy N, Andras P. The role of nitric oxide in abnormal T cell signal transduction in systemic lupus erythematosus[J]. Clin Immu, 2006, 118(2-3):145-151. 被引量:1
  • 6Demple B. Signal transduction by nitric oxide in cellular stress responses[J]. Mol Cell Biochem, 2002, 234-235(1-2): 11-18. 被引量:1
  • 7Quijano C, Romero N, Radi R. Tyrosine nitration by superoxide and nitric oxide fluxes in biological systems: modeling the impact of superoxide dismutase and nitric oxide diffusion [J]. Free Radic Biol Med, 2005, 39(6):728-741. 被引量:1
  • 8Bayir H , Kagan VE, Tyurina YY, etal. Reactive oxygen species and sepsis[J]. Crit Care Med, 2005,33:498-501. 被引量:1
  • 9Hansen JM, Go YM, Jones DP. Nuclear and mitochondrial compartmentation of oxidative stress and redox signaling[J]. Annu Rev Pharmacol Toxicol, 2006, 46(4):215-234. 被引量:1
  • 10Singh DK, Kumar D, Siddiqui Z, et al. The strength of receptor signaling is centrally controlled through a cooperative loop between Ca2+ and an oxidant signal[J]. Cell, 2005, 121(2):281-293. 被引量:1

共引文献9

同被引文献33

引证文献7

二级引证文献12

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部