摘要
目的检测妊娠期糖尿病(GDM)孕妇与正常健康孕妇血浆及脐血中网膜素1的水平,探讨其在GDM发病过程中的作用及其与胰岛素抵抗的相关性。方法选取GDM孕妇39例为GDM组,正常健康孕妇44例为NGT组。根据孕妇孕前的体质量指数(BMI)将上述2组分为体质量正常组和肥胖组,用酶联免疫吸附(ELISA)方法测定血浆及脐血中网膜素1的浓度、空腹血糖(FBG)、空腹胰岛素(FINS)、OGTT后1 h血糖及2 h血糖,计算胰岛素抵抗指数(HOMA-IR)。结果 GDM肥胖组网膜素1水平明显低于GDM体质量正常组(P<0.01);GDM体质量正常组孕妇血浆网膜素1水平明显低于NGT体质量正常组(P<0.01);GDM组孕妇血中胰岛素、血糖、HOMA-IR与NGT组比较差异有统计学意义(P均<0.05);孕妇网膜素1浓度与孕妇BMI、FBG、FINS、OGTT后1 h血糖水平、HOMA-IR呈显著负相关性(P<0.05)。孕妇及脐血网膜素1与新生儿出生体质量无明显相关性。结论 GDM孕妇尤为肥胖者血清网膜素1水平下降,可能为早期检测GDM提供一种新的方法。
Objective It is to determine the level of omentin 1 in the patients with gestational diabetes mellitus（GDM）and normal healthy pregnant women,and to explore its effect in the development of GDM and its relationship with insulin resistance.Methods 39 pregnant women with GDM were selected as GDM group and 44 healthy pregnant subjects were selected as NGT group.According to BMI of the women before pregnancy the two groups were divided into obese group and normal weight group.The content of omentin 1,FBG,FINS,1 h BG and 2 h BG after OGTT were determined by ELISA,and HOMA-IR was calculated.Results The level of omentin 1 in GDM obese group was significantly lower than that in GDM normal weight group（P〈0.01）,while the level was obviously lower in GDM normal weight group than that in NGT normal weight group（P〈0.01）.There were significant differences in blood insulin,blood sugar and HOMA-IR between GDM group and NGT group（P 0.05）.In the pregnant women,omentin 1 was significantly negatively correlated with BMI,FBG,FINS,1 h BG after OGTT and HOMA-IR（P 0.05）.There was no obvious correlation between omentin 1 in pregnant women and cord blood and fetal birth weight.Conclusion Omentin concentration decreases in maternal serum of women with GDM,especially in obese ones,and this may provide a novel approach to identify women with GDM and obese.
出处
《现代中西医结合杂志》
CAS
2014年第29期3217-3219,共3页
Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词
妊娠期糖尿病
肥胖
网膜素
胎血
gestational diabetes
obesity
omentin
fetal blood
