摘要
目的探讨妊娠早期进行糖脂代谢指标监测对妊娠期糖尿病(gestational diabetes mellitus,GDM)的临床预测价值。方法选取88例收治的妊娠期糖尿病患者,设为观察组;同时挑选同时间段内在本院进行产检并分娩的正常妊娠期妇女88例,设为对照组。对两组产妇进行以下指标的检测:糖化血红蛋白(Hemoglobin A1c,HbA1c)、空腹血糖(Fasting blood glucose,FPG)、口服75g葡萄糖后1h、2h血糖、甘油三酯(Triglyceride,TG)、总胆固醇(Total cholesterol,TC)、高密度脂蛋白胆固醇(High density lipoprotein cholesterol,HDL-C)及低密度脂蛋白胆固醇(Low density lipoprotein cholesterol,LDL-C)。对比两组孕妇不良妊娠结局及新生儿结局发生情况。分析妊娠早期糖脂生化指标与75g OGTT血糖值、新生儿结局的相关性。结果观察组孕妇HbA1C、FPG、口服75g葡萄糖后1h、2h血糖水平明显高于对照组(P<0.05)。观察组孕妇TC、TG、LDL-C水平明显高于对照组(P<0.05)。观察组孕妇羊水过多、宫内窘迫、胎膜早破及早产发生率与对照组比较明显较高(P<0.05)。观察组孕妇剖宫产、巨大儿及低出生体重儿发生率与对照组比较明显较高(P<0.05)。经Pearson相关分析显示,FPG、HbA1c、TG水平与75g OGTT血糖值呈显著正相关(P<0.05)。经Logistic回归分析显示,妊娠早期糖脂生化指标与新生儿结局具有明显相关性。结论GDM孕妇在妊娠早期的糖脂代谢指标明显高于正常孕妇,其妊娠早期FPG、HbA1c、TG水平与母婴结局具有密切相关性,在妊娠早期对这些糖脂代谢指标进行检测对于预测GDM病情发生、发展及新生儿结局具有重要临床价值。
Objective To explore the clinical predictive value of glycolipids biochemical indexes detection on gestational diabetes mellitus(GDM).Methods A total of 88 patients with GDM were selected as the observation group,and another 88 women with normal gestation who received birth examination and delivery in our hospital during the same period were selected as the control group.The glycated hemoglobin(HbA1C),fasting plasma glucose(FPG),blood glucose level at 1 and 2 hours after oral administration of 75 g glucose,triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipids cholesterol(LDL-C)levels of two groups were detected.The incidence of adverse pregnancy outcomes and neonatal outcomes of the two groups were compared.The correlation between glycolipid biochemical indicators and the blood glucose of 75 g OGTT and neonatal outcome was analyzed.Results The HbA1C,FPG and blood glucose level at 1 and 2 hours after oral administration of 75 g glucose in the observation group were significantly higher than those in the control group(P<0.05).The TC,TG and LDL-C levels in the observation group were significantly higher than those in the control group(P<0.05).The incidences of excessive amniotic fluid,intrauterine distress,premature rupture of membranes and premature birth in the observation group were significantly higher than those in the control group(P<0.05).The incidences of caesarean section,macrosomia and low birth weight infants in the observation group were significantly higher than those in the control group(P<0.05).Pearson correlation analysis showed that FPG,HbA1c and TG levels were positively correlated with 75 g OGTT blood glucose(P<0.05).Logistic regression analysis showed that the glycolipid biochemical indicators in early pregnancy had significant correlation with neonatal outcomes.Conclusions The glycolipid biochemical indicators in GDM pregnant women in early pregnancy are significantly higher than those in the normal maternal,and the FPG,HbA1c and TG levels are clos
作者
刘小燕
林律初
陈树华
LIU Xiao-yan(Laboratory of Yunfu people’s Hospital,Yunfu 527300,China)
出处
《牡丹江医学院学报》
2020年第1期64-68,共5页
Journal of Mudanjiang Medical University
关键词
糖尿病
妊娠
糖化血红蛋白
甘油三酯
总胆固醇
高密度脂蛋白胆固醇
低密度脂蛋白胆固醇
Diabetes Mellitus
Pregnancy
Glycated Hemoglobin
Triglycerides
Total Cholesterol
High-Density Lipoprotein Cholesterol
Low-Density Lipoprotein Cholesterol
