摘要
目的探讨分析引发乙醇性肝硬化患者肺部感染的危险因素以及预防与控制感染措施,以降低肺部感染率。方法选取2009年1月-2012年12月收治的110例乙醇性肝硬化患者为研究对象,将其中发生肺部感染的35例患者为感染组,余75例为未感染组,采用logistic回归分析法对乙醇性肝硬化患者肺部感染的相关因素进行统计分析。结果 110例乙醇性肝硬化患者中发生肺部感染35例,感染率为31.8%;35例感染患者中发热、外周血白细胞计数〉10×10^9/L、咳嗽、咳痰的阳性率分别为57.1%、51.4%、48.6%;共培养出病原菌19株,其中革兰阴性菌占68.4%,革兰阳性菌占21.1%,真菌占10.5%;肺部感染的发生与年龄、住院时间、肝衰竭、消化道出血、细菌性腹膜炎、肝性脑病及合并基础疾病有关（P〈0.05）,与性别无明显相关性;采用非条件logistic回归分析法结果发现,年龄（OR=5.791,95%CI=1.704～19.681）、住院时间（OR=4.335,95%CI=1.341～14.017）、肝衰竭（OR=4.338,95%CI=1.012～19.198）、消化道出血（OR=6.909,95%CI=1.643～29.053）、细菌性腹膜炎（OR=5.593,95%CI=1.189～26.311）、肝性脑病（OR=3.939,95%CI=1.162～13.424）、合并基础性疾病（OR=5.259,95%CI=1.602～17.072）是乙醇性肝硬化患者住院期间肺部感染的主要危险因素（P〈0.05）。结论乙醇性肝硬化患者肺部感染率较高,医务人员要充分认识其危险因素,以预防和控制其发生。
OBJECTIVE To discuss the risk factors of pulmonary infections in patients with alcoholic cirrhosis during hospitalization and the measures of preventing and controlling infections,so as to reduce the occurrence of pulmonary infections.METHODS 110 patients with alcoholic cirrhosis enrolled from January 2009 to December2012in our hospital were the research subjects;35cases with the pulmonary infections as the infected group,and the remaining 75 cases as the non-infected group.The related risk factors of pulmonary infections in patients with alcoholic cirrhosis were statistically analyzed by logistic regression method.RESULTS There were 35 cases with pulmonary infections among 110 patients with alcoholic cirrhosis with an infection rate of 31.8%.For the 35 infected cases with fever,the positive rates of WBC count〉10×10^9/L,cough,sputum were 57.1%,51.4%,48.6%respectively;a total of 19 pathogens were cultured,including the gram-negative bacteria（68.4%）,gram positive bacteria（21.1%）and fungi（10.5%）;the pulmonary infection was associated with age,hospitalization duration,liver failure,gastrointestinal bleeding,spontaneous bacterial peritonitis,hepatic encephalopathy and accompanied with basic diseases（P〈0.05）,not associated with sex（P〉0.05）.Unconditional logisticregression analysis found that age（OR=5.791,95%CI=1.704～19.681）,hospitalization duration（OR=4.335,95%CI=1.341～14.017）,liver failure（OR=4.338,95%CI=1.012～19.198）,gastrointestinal bleeding（OR=6.909,95%CI=1.643～29.053）,bacterial peritonitis（OR=5.593,95%CI=1.189～26.311）,hepatic encephalopathy（OR=3.939,95%CI=1.162～13.424）and accompanied with basic diseases（OR=5.259,95%CI=1.602～17.072）were major risk factors of pulmonary infections in patients with alcoholic cirrhosis during hospitalization（P〈0.05）.CONCLUSIONThere is a high incidence of pulmonary infections in patients with alcoholic cirrhosis during hospitalization.The medical staff should have been fully aware of the risk factors to prevent a
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2014年第19期4782-4784,共3页
Chinese Journal of Nosocomiology
基金
十二五国家科技重大专项基金资助项目(2012ZX10002003)
关键词
乙醇性肝硬化
肺部感染
危险因素
Alcoholic cirrhosis
Pulmonary infection
Risk factors
