摘要
目的探讨肝硬化患者合并感染的危险因素。方法以2004年10月-2008年10月184例肝硬化住院患者为研究对象,采用病例对照的研究方法,回顾性分析感染发生情况和危险因素。结果 64例患者合并细菌感染,感染率34.8%;感染类型主要包括呼吸道感染44例(68.8%),自发性腹膜炎12例(18.8%),标本培养10例阳性结果,革兰染色阴性菌6例,革兰染色阳性菌4例;Logistic多因素分析显示,Child-Pugh分级为C级、年龄>55岁、脾大/脾切除、病毒性肝炎、上消化道出血史是相对独立危险因素,OR值(95%CI)依次为3.341(1.529～7.300)、2.912(1.313～6.460)、2.691(1.164～6.221)、2.651(1.191～5.902)、2.162(1.060～4.410)。结论重视肝硬化患者的病情分级、年龄、病因、并发症,更好地预防控制肝硬化合并感染。
OBJECTIVE To explore the risk factors for infections in patients with cirrhosis.METHODS A total of 184 patients with cirrhosis from Oct 2004 to Oct 2008 were collected as the study object,a case-control study was employed to retrospectively assess the infection and risk factors.RESULTS Infections developed in 64（34.8%） patients.44（68.8%） patients had upper respiratory tract infections,and 12（18.8%） patients had spontaneous bacterial peritonitis.Bacterial culture of samples was positive in 10 patients.Six samples were with Gram-negative bacteria strains,and 4 samples were with Gram-positive bacteria strains.On Logistic analysis,Child-Pugh score was C,the age over 55 years,splenomegaly/splenectomy,virus hepatitis,and upper gastrointestinal hemorrhage were the independent risk factors.The odds ratio was 3.341（1.529-7.300）,2.912（1.313-6.460）,2.691（1.164-6.221）,2.651（1.191-5.902）,2.162（1.060-4.410）,respectively.CONCLUSIONS In order to prevent and control the infections better,Child-Pugh score,age,etiology,and complication of patients with cirrhosis.Should be paid accention to.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2010年第15期2216-2218,共3页
Chinese Journal of Nosocomiology
关键词
肝硬化
感染
危险因素
Cirrhosis
Infection
Risk factors
