摘要
以氯化铟为催化剂,通过芳基腈和叠氮化钠的[3+2]环加成反应合成了一系列5-芳基四氮唑,含各种官能团的底物都可以获得高产率.此合成方法还对酯的分解有催化效果,可以在合成四氮唑的同时对酯进行脱保护获得羧酸和醇.
5-Phenyl-1H-tetrazoles were synthesized by catalytic [3＋2] cycloaddition with aryl nitriles and sodium azide. Indium trichloride was used as an efficient catalyst. The tetrazoles binding with varieties of functional groups were synthesized in good to quantitative yields. This tetrazole synthetic protocol also showed remarkable de-carboxylation activity. Esters were cleaved to carboxylic acids or alcohols in one pot.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2014年第9期1889-1894,共6页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.21003018)资助项目~~
关键词
氯化铟
催化
四氮唑
合成
[3+2]环加成
酯分解
indium trichloride
catalysis
tetrazole
synthesis
[3 ＋2] cycloaddition
cleavage of ester
