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PPAR激活物对颅脑损伤的神经保护作用研究进展 被引量：1

Recent advances in neuroprotective effect of peroxisome proliferator-activated receptor activators on craniocerebral injury
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摘要 战时重型颅脑伤发生率高,占全身伤总数的10％～20％,死亡率高达35％～60％,居战伤阵亡中首位,是青壮年人群的首要死亡原因[1].目前,有关重型颅脑伤的救治,主要为对继发性脑损害的治疗.颅脑外伤后产生多种细胞和生化反应,主要有免疫细胞的介入和激活、神经元和胶质细胞的死亡、线粒体功能障碍和抑制轴索物质的释放等.过氧化物酶体增殖物激活受体（peroxisome proliferator-activated receptor,PPAR）是一组配体激活的转录因子受体,尽管不能影响创伤性脑损伤全部的信号,但能影响多条相关的病理过程,如调整免疫细胞、激活代谢和线粒体功能、促进轴索生长并诱导前体细胞向少突胶质细胞的分化等,因此,可以推测PPAR激活物对于颅脑损伤具有一定的神经保护作用.
作者 周杰 杨晓亮 荔志云
机构地区 兰州军区兰州总医院神经外科
出处 《中华神经医学杂志》 CAS CSCD 北大核心 2014年第9期965-968,共4页 Chinese Journal of Neuromedicine
关键词 过氧化物酶体增殖物激活受体 颅脑损伤 神经保护 Peroxisome proliferator-activated receptor Craniocerebral injury Neuroprotective effect
分类号 R651.15 [医药卫生—外科学]
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参考文献35

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共引文献16

同被引文献11

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中华神经医学杂志
2014年 第9期

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